Transneuronal retrograde degeneration of retinal ganglion cells following cerebral hemispherectomy in cats

Brain Research
H ThéoretM Ptito

Abstract

We have assessed the extent of transneuronal retrograde degeneration of retinal ganglion cells (RGCs) following the removal of a whole cerebral hemisphere at postnatal age 16 and 25 days. In the P16 animal, the nasal retina contralateral to the lesion suffered a 41% cell loss, whereas cell loss in the temporal retina ipsilateral to the lesion was 33%. Cell loss was greater in nasal retina and mainly included medium sized cells (200-600 microns2). In the P25 animal overall there was no evidence for ganglion cell loss.

Citations

Jan 10, 2013·PloS One·Yuyi YouAlexander Klistorner
Feb 24, 2017·Current Neurology and Neuroscience Reports·Marc Dinkin
Apr 28, 2018·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Stephen J Vincent, Damien Fisher

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