Abstract
To determine the prognostic influence of p16(INK4a) immunohistochemistry on the survival of resectable oropharyngeal carcinomas (OPSCC). Retrospective pathologic evaluation of a prospective single-arm cohort study at a tertiary referral center. There were 48 patients with resectable OPSCC who consented for transoral robotic surgery (TORS) and banked tissue specimen for assessment. TORS was with or without adjuvant radiation or chemoradiation. Main outcome measures were p16(INK4a) status, human papillomavirus status, local-regional disease control, and overall, disease-specific, and disease-free survival. p16(INK4a) and HPV positivity were identified in 73% and 74% of patients respectively. With a median follow-up of 38.8 months (2.5-63.3 months), only one local-regional relapse has occurred in both the p16(INK4a)-positive and p16(INK4a) -negative cohorts. No disease-specific, disease-free, and overall survival differences were observed between p16(INK4a) -positive and p16(INK4a)-negative patients (P = .446, P = .277, P = .643, respectively). p16(INK4a) was not prognostic in resectable OPSCC when treated with an initial TORS approach.
References
Mar 24, 1998·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J OvergaardK Jørgensen
May 4, 2000·Journal of the National Cancer Institute·M L GillisonD Sidransky
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·R KlaesM von Knebel Doeberitz
Sep 11, 2001·Cancer·K LindelD M Aebersold
Feb 25, 2003·The American Journal of Pathology·Jens P KlussmannPawel G Fuchs
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Wei LiBarbara R Rose
Dec 20, 2003·Pharmacogenomics·Richard Obiso, Attila Lorincz
Aug 4, 2006·The Laryngoscope·Bert W O'MalleyNeil G Hockstein
Dec 21, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa LicitraSilvana Pilotti
Jun 15, 2007·Head & Neck·Eisaku HiguchiSatoshi Fukuda
Dec 19, 2007·Archives of Otolaryngology--head & Neck Surgery·Gregory S WeinsteinHarry Quon
Feb 14, 2008·Journal of the National Cancer Institute·Carole FakhryMaura L Gillison
May 14, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bhavna KumarThomas E Carey
Mar 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pernille LassenJens Overgaard
Jun 2, 2009·International Journal of Radiation Oncology, Biology, Physics·Anjali K GuptaDouglas R Spitz
Jul 3, 2009·The Laryngoscope·Jason T RichBruce H Haughey
Jul 31, 2009·Cancer Prevention Research·Kathleen SettleKevin J Cullen
Aug 22, 2009·International Journal of Cancer. Journal International Du Cancer·Claude A FischerLuigi M Terracciano
Oct 31, 2009·International Journal of Cancer. Journal International Du Cancer·Elaine M SmithLubomir P Turek
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wei ShiFei-Fei Liu
Nov 17, 2009·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pernille LassenUNKNOWN Danish Head and Neck Cancer Group (DAHANCA)
Aug 11, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danny RischinGrant A McArthur
Nov 17, 2010·Archives of Otolaryngology--head & Neck Surgery·Gregory S WeinsteinHarry Quon
Mar 23, 2011·Head & Neck·Marc A CohenHarry Quon
Citations
Feb 13, 2014·British Journal of Cancer·C Grønhøj LarsenC von Buchwald
Mar 7, 2013·International Journal of Clinical Oncology·Tomoya YokotaHirofumi Yasui
Apr 8, 2014·Current Oncology Reports·Monica George
Jan 4, 2013·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Dana M HartlAlfio Ferlito
Oct 30, 2014·Head & Neck·Chaz L StuckenEric M Genden
Jul 6, 2014·Head & Neck·Jose P ZevallosElizabeth Y Chiao
Jul 18, 2015·Oral Oncology·Sandy Z LiuKevin J Cullen
May 15, 2015·Annals of Surgical Oncology·Balazs B LörinczRainald Knecht
Dec 22, 2015·ANZ Journal of Surgery·Lisa BuckleyJonathan R Clark
Mar 19, 2016·Clinical Oncology : a Journal of the Royal College of Radiologists·M Evans, T M Jones
Jun 24, 2014·Head & Neck·Balazs B LörinczRainald Knecht
Mar 13, 2014·Cancer Medicine·Georgios PsychogiosHeinrich Iro
Apr 15, 2014·The Laryngoscope·John R de AlmeidaEric M Genden
Oct 6, 2015·The Laryngoscope·Richard V SmithMissak Haigentz
Dec 10, 2014·Head & Neck·John R de AlmeidaEric M Genden
Oct 2, 2013·Cancer Treatment Reviews·Aru PanwarApar Kishor Ganti
Mar 12, 2015·Current Opinion in Otolaryngology & Head and Neck Surgery·Michael L HinniBrittany Howard
Aug 18, 2016·Oral Oncology·Matthew C Ward, Shlomo A Koyfman
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F Christopher Holsinger, Robert L Ferris
Jul 1, 2017·International Journal of Oral Science·Hang-Hang LiuEn Luo
Jul 1, 2015·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Marilene B WangChau T Nguyen
Mar 11, 2020·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Thomas J GalBin Huang
Aug 24, 2016·Genes & Cancer·Nicole L MichmerhuizenJ Chad Brenner
Jul 19, 2015·Current Treatment Options in Oncology·Yan Monnier, Christian Simon
Mar 29, 2016·Laryngoscope Investigative Otolaryngology·Yuki SaitoTatsuya Yamasoba
Sep 24, 2019·Oral Oncology·Philippe Gorphe, Christian Simon
Apr 24, 2021·PloS One·Guadalupe Lorenzatti HilesHeather M Walline
Aug 8, 2021·Cancers·Christine GoudsmitHeather Walline