Transperineal template prostate-mapping biopsies: an evaluation of different protocols in the detection of clinically significant prostate cancer

BJU International
Massimo ValerioHashim U Ahmed

Abstract

To determine whether modified transperineal template prostate-mapping (TTPM) biopsy protocols, altering the template or the biopsy density, have sensitivity and negative predictive value (NPV) equal to full 5-mm TTPM. Retrospective analysis of an institutional registry including treatment-naïve men undergoing 5-mm TTPM biopsy analysed in a 20-zone fashion. The value of three modified strategies was assessed by comparing the information provided by selected zones against full 5-mm TTPM. Strategy 1, did not consider the findings of anterior areas; strategies 2 and 3 simulated a reduced biopsy density by excluding intervening zones. A bootstrapping technique was used to calculate reliable estimates of sensitivity and NPV of these three strategies for the detection of clinically significant disease (maximum cancer core length ≥4 mm and/or Gleason score ≥3 + 4). In all, 391 men with a median (interquartile range, IQR) age of 62 (58-67) years were included. The median (IQR) PSA level and PSA density were 6.9 (4.8-10) ng/mL and 0.17 (IQR 0.12-0.25) ng/mL/mL, respectively. A median (IQR) of 6 (2-9) cores out of 48 (33-63) taken per man were positive for prostate cancer. No cancer was detected in 67 men (17%), whilst low-, intermediate-...Continue Reading

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Citations

Mar 26, 2016·World Journal of Urology·D A Smit DuijzentkunstM van Vulpen
Mar 5, 2017·BJU International·Abi KanthabalanHashim Uddin Ahmed
Feb 6, 2018·World Journal of Urology·Ilaria JansenPatricia J Zondervan
Dec 12, 2018·The American Journal of Surgical Pathology·Luis BeltranUNKNOWN Transatlantic Prostate Group
Apr 21, 2020·Prostate Cancer·Maudy C W GayetHessel Wijkstra
Jan 13, 2018·Virchows Archiv : an International Journal of Pathology·Solene-Florence Kammerer-JacquetDaniel M Berney

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