PMID: 8584503Aug 1, 1995Paper

Transplacental and lactational exposure to mercury in hamster pups after maternal administration of methyl mercury in late gestation

Pharmacology & Toxicology
K NordenhällM Vahter

Abstract

Pregnant Syrian golden hamsters were given a single oral dose of 203Hg-labelled methyl mercury (MeHg), 1.6 mumol/kg body weight, on day 12 of gestation. The uptake, retention and tissue distribution of 203Hg in the dams and pups was studied by gamma-counting during the following three weeks. The average transplacental transfer of 203Hg was 1.1% of the administered dose per pup, corresponding to 11% of the administered dose to a whole litter. This was considerably more than in our previous studies when the dams were treated on gestational day 2 (1.3%) or 9 (4.6%). The amount of 203Hg transferred to each pup in utero was independent of the litter size. The average additional transfer of 203Hg to a litter via milk was 1.7% of the administered dose. In the pups, the content of 203Hg in the liver and brain decreased, while the content in the kidneys and pelt increased during the second and third week. The highest amount of 203Hg was generally found in the pelt, which indicated that unweaned hamster pups primarily excrete MeHg by binding to hair. The chemical form of mercury in the liver and kidneys of the pups was determined by ion-exchange separation of inorganic Hg and MeHg followed by gamma-counting. The amount of inorganic Hg in...Continue Reading

References

Jan 1, 1979·Annual Review of Pharmacology and Toxicology·T P GreenB L Mirkin
Apr 1, 1990·Environmental Research·C Y ShiT W Clarkson
Jul 1, 1989·Biological Trace Element Research·K PeterssonM Vahter
Jan 1, 1989·Progress in Neurobiology·B H Choi
Aug 1, 1988·Archives of Toxicology·M Inouye, Y Kajiwara
Apr 1, 1987·Environmental Research·N K MottetT M Burbacher
Oct 1, 1985·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·N Ballatori, T W Clarkson
Jun 1, 1983·Environmental Research·K KostialM Landeka
Mar 15, 1982·Toxicology and Applied Pharmacology·D J ThomasP Mushak
Aug 1, 1982·Journal of Toxicology and Environmental Health·B J KelmanL B Sasser
Jul 1, 1980·Toxicology and Applied Pharmacology·A NaganumaN Imura
Jan 1, 1995·Archives of Toxicology·K NordenhällM Vahter

❮ Previous
Next ❯

Citations

Mar 26, 2004·Ecotoxicology and Environmental Safety·José G Dórea
Oct 1, 1998·Environmental Toxicology and Pharmacology·A C Barbosa, J G Dórea
Jun 9, 2014·Environment International·Yu-Sheng LinBabasaheb Sonawane
Jul 15, 2015·Archives of Environmental Contamination and Toxicology·Marie NoëlPeter S Ross
Jan 5, 2010·Environmental Toxicology and Pharmacology·Sun Ku LeeRaymond S H Yang
Jul 3, 2004·The British Journal of Nutrition·José G Dorea
Sep 2, 2003·Environmental Health Perspectives·Alan H Stern, Andrew E Smith
Apr 24, 2007·Neurotoxicity Research·Carolina JohanssonSandra Ceccatelli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
E LutzM Vahter
European Journal of Pediatrics
S Halbach, K H Summer
© 2021 Meta ULC. All rights reserved