Transplacental effect of stobadine on cyclophosphamide induced micronucleus frequency in mice

Mutagenesis
D Chorvatovicová, E Ujházy

Abstract

The transplacental effect of stobadine (STB) on micronucleus (MN) frequency was studied in fetuses of ICR mice injected with cyclophosphamide (CP). STB, dissolved in methylcellulose, was administered orally from gestational day 11 until day 17 in two concentrations (23.6 and 70.07 mg/kg body wt) 2 h prior to CP administration (i.p., 10 mg/kg body wt). In fetal liver and in maternal bone marrow the frequencies of MN in polychromatic erythrocytes were significantly decreased in both STB-pretreated groups injected with CP compared to the CP group pretreated with methylcellulose. The higher concentrations of STB was more efficient, but the difference was not significant. In the CP-treated groups, fetal MN frequencies were about three times higher than in maternal bone marrow. Mouse fetuses thus proved to be far more susceptible to the clastogenic effect of CP. The protective effect of STB against CP mutagenicity was confirmed in fetuses of CP-treated female ICR mice. These results are discussed with respect to fetal development and maternal/fetal metabolism.

Citations

Jul 16, 1999·Teratogenesis, Carcinogenesis, and Mutagenesis·M M Dobrzyńska, A K Gajewski
Nov 27, 1999·Life Sciences·D ChorvatovicováD Slamenová
Jul 24, 1998·Mutation Research·J M GentileL R Ferguson
Apr 29, 1998·General Pharmacology·L Horáková, S Stolc
Jul 28, 2004·Environmental and Molecular Mutagenesis·Belinda C Gómez-MedaBlanca M Torres-Mendoza

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antianginal Drugs: Mechanisms of Action

Antianginal drugs, including nitrates, beta-blockers, and calcium channel blockers, are used in the treatment of angina pectoris. Here is the latest research on their use and their mechanism of action.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.