Transplacental effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the temporal modulation of Sp1 DNA binding in the developing cerebral cortex and cerebellum

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie
Tultul NayyarDarryl B Hood

Abstract

Gestational exposure to environmental pollutants such as 2,3,7,8-tetrachlorodibenzo-p-dioxin, (dioxin) often leads to neurodevelopmental and neurobehavioral deficits, which clearly suggest the involvement of the central nervous system. The objective of this study was to determine the effects of an acute, gestational exposure to dioxin on the developmental expression profile of a transcription factor (Sp1) that is involved in growth and differentiation in the developing brain of F, generation pups. Timed-pregnant Harlan Sprague Dawley rats were exposed to single oral doses of 0.25, 0.5, and 1.0 microg dioxin/kg body weight or vehicle corn oil on gestation day 15. Electrophoretic mobility shift assays (EMSA) of the nuclear extracts from the cerebral cortex and cerebellum of the resulting pups, on postnatal days (PND) 3.5, 10, 15, 20 and 30, with an Sp1 consensus oligonucleotide sequence revealed modulations in the DNA binding activity of Sp1 as a result of the transplacental dioxin exposure. In the cerebral cortex, a dose-dependent premature peak of Sp1 DNA-binding on PND 3 was observed when compared with the control animals where Sp1 DNA-binding was maximal on PND 10. In the postnatally-developing cerebellum, a dose-dependent pr...Continue Reading

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Citations

Jan 30, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Loretta L CollinsLisa A Opanashuk
Nov 5, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xueqian WangDavid S Miller
Apr 3, 2009·The Journal of Clinical Investigation·Pat Levitt, Daniel B Campbell
May 27, 2010·PLoS Computational Biology·Karine AudouzeSøren Brunak
May 6, 2004·Toxicology and Applied Pharmacology·Deanna D WormleyDarryl B Hood
Aug 27, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Meghan E Rebuli, Heather B Patisaul
Jul 10, 2016·Neurotoxicology·Antonio Morales-HernándezJaime M Merino
Jul 9, 2008·Development and Psychopathology·Dante Cicchetti, Megan R Gunnar
Sep 19, 2012·Apoptosis : an International Journal on Programmed Cell Death·Antonio Morales-HernándezJaime M Merino
Feb 21, 2014·Pharmacological Reports : PR·Małgorzata Kajta, Anna K Wójtowicz
Aug 21, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Jie WuDarryl B Hood

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