Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation

The Journal of Clinical Investigation
Kyle T MinchamD H Strickland

Abstract

Chronic allergic inflammatory diseases are a major cause of morbidity, with allergic asthma alone affecting over 300 million people worldwide. Epidemiological studies demonstrate that environmental stimuli are associated with either the promotion or prevention of disease. Major reductions in asthma prevalence are documented in European and US farming communities. Protection is associated with exposure of mothers during pregnancy to microbial breakdown products present in farm dusts and unprocessed foods and enhancement of innate immune competence in the children. We sought to develop a scientific rationale for progressing these findings toward clinical application for primary disease prevention. Treatment of pregnant mice with a defined, clinically approved immune modulator was shown to markedly reduce susceptibility of their offspring to development of the hallmark clinical features of allergic airway inflammatory disease. Mechanistically, offspring displayed enhanced dendritic cell-dependent airway mucosal immune surveillance function, which resulted in more efficient generation of mucosal-homing regulatory T cells in response to local inflammatory challenge. We provide evidence that the principal target for maternal treatmen...Continue Reading

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Citations

Sep 6, 2020·International Journal of Molecular Sciences·James F Read, Anthony Bosco
Oct 3, 2020·European Respiratory Review : an Official Journal of the European Respiratory Society·Niki D J UbagsJennifer J P Collins
Mar 3, 2020·Frontiers in Immunology·April C ApostolAnna E Beaudin
Apr 26, 2020·The Journal of Allergy and Clinical Immunology·Patrick G HoltAdnan Custovic
Jun 24, 2021·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Kyle T MinchamDeborah H Strickland
Jul 13, 2021·Clinical & Translational Immunology·Jean-Francois Lauzon-JosetDeborah H Strickland
Jul 27, 2021·The Journal of Allergy and Clinical Immunology·Yuan GaoPeter Vuillermin
Oct 23, 2021·Frontiers in Immunology·Emma L LewisMichal A Elovitz

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Methods Mentioned

BETA
bronchoalveolar lavage
flow cytometry
FCS

Software Mentioned

GraphPad
Cytobank
GraphPad Prism
FlowJo
Tree Star

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