PMID: 489170Sep 15, 1979Paper

Transplacental mutagenesis of products formed in the stomach of golden hamsters given sodium nitrite and morpholine

International Journal of Cancer. Journal International Du Cancer
N InuiA Tanimura

Abstract

Hamster embryos were exposed in utero to the action of sodium nitrite (NaNO2) and morpholine (Mo) administered simultaneously by stomach tube to the mothers on the 11th or 12th day of pregnancy. Embryo cells were examined for chromosomal aberrations, micronuclear formation, morphological or malignant transformation and drug resistance mutations. For detection of induced mutations, the embryo cells were cultured in normal medium for 72 h and then transferred to medium containing 10 or 20 micrograms/ml of 8-azaguanine (8AG) or 1m7 ouabain (Oua). The number of 8AG-, Ouaresistant colonies was markedly increased after administration of NaNO2 and Mo. The embryonic fibroblasts also showed a markedly increased frequency of micronucleation and a slight increase in chromosome aberrations. This treatment also caused morphological or malignant transformation of fetal cells. After cultivation in vitro, cells from some transformed colonies produced tumors when inoculated into the cheek pouch of young golden hamsters. Orally administered N-nitroso-morpholine (N-Mo), as a positive control, had the same transplacental biological actions on embryonic fibroblasts. However, transplacentally Mo alone was ineffective. A single administration of 500 ...Continue Reading

References

Feb 1, 1975·Mutation Research·W Schmid
Aug 15, 1975·International Journal of Cancer. Journal International Du Cancer·H W Taylor, W Lijinsky
Oct 1, 1977·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·N MatsukuraN Ito
Mar 30, 1978·Biochemical and Biophysical Research Communications·N InuiT Yamada
Aug 1, 1974·Toxicology and Applied Pharmacology·D R StoltzH C Grice
Jan 1, 1973·Advances in Cancer Research·C Heidelberger
Mar 1, 1958·Stain Technology·K H ROTHFELS, L SIMINOVITCH

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Citations

Jan 1, 1986·Mutation Research·M C CiminoJ C Liang
Jun 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M HayashiM Ishidate
Sep 1, 1989·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·D Grant, W H Butler
Dec 13, 2006·Mutation Research·Giovanni Brambilla, Antonietta Martelli

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