PMID: 45257Dec 1, 1979

Transplacental passage of cells from mother to fetus: experimental approach and initial results in the rat

Bulletin de l'Association des anatomistes
H Gérard, F Kohler

Abstract

The consequences of transfusion across the placenta of maternal cells to fetuses, supposed to elicit a Graft-Versus-Host-Reaction, are poorly investigated; the injection of pregnant rat whole blood cells to its own fetuses is proposed here as a convenient experimental model to improve the understanding of these consequences; indeed this technic is reliable as well as easy enough to carry out experiments on large samples. Preliminary results indicate that the injection is often followed by a runting disease, a thymic atrophy and a liver hypertrophy; splenomegaly does not occur. On the histologic level, the main features are as follows 1) modification of central lymphoïd organs, 2) blastic and/or granulocytic infiltrates of several other organs, namely the liver, the adrenal cortex and the thyroïd gland.

Related Concepts

Fetal Structures
Entire Fetus
Placenta Specimen
Hypertrophy
Placenta
Graft Vs Host Reaction
Organ
Infiltration
Granulocyte
Entire Placenta

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