PMID: 1202623Dec 1, 1975Paper

Transplacental passage of foetal blood cells

Scandinavian Journal of Haematology
R ZilliacusE Kleihauer

Abstract

With the brightly fluorescent Y chromatin as a marker, the proportion of foetal lymphocytes in maternal blood was found to be 0.02-0.16% in 7 of 11 primigravidae bearing a boy, but not a single XY mitosis was found among 112,000 leucoagglutinin-stimulated mitoses from the same women. The proportion of foetal lymphocytes did not change appreciably during pregnancy (first appearance detected at 15 weeks' gestation), nor were there any unequivocal foetal erythrocytes in spite of ABO and Rh compatibility. These findings suggest that foetal lymphocytes pass actively into the mother's blood relatively early during pregnancy. The cells are protected from immunological elimination, and therefore may remain in the maternal blood for long periods. They are a valuable potential source of material for antenatal foetal diagnosis.

References

Jan 1, 1975·Scandinavian Journal of Immunology·J Schröder
Sep 1, 1975·Scandinavian Journal of Immunology·R ZilliacusA Tiilikainen
Sep 1, 1974·American Journal of Obstetrics and Gynecology·L GrossetN Odartchenko
Apr 1, 1974·Experimental Cell Research·T H WeberK Lindahl-Kiessling
May 1, 1966·British Journal of Haematology·J C Woodrow, R Finn
Aug 1, 1970·Experimental Cell Research·T CasperssonM Hultén
Jan 1, 1971·Annual Review of Genetics·J H Renwick

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Citations

Dec 1, 1994·Prenatal Diagnosis·J L Simpson, S Elias
Jan 1, 1981·Animal Blood Groups and Biochemical Genetics·H C Hines, M J Newman
Jan 13, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Svitlana Garbuzova-DavisPaul R Sanberg
Aug 1, 1992·Nature Genetics·M Adinolfi
Dec 1, 1992·Prenatal Diagnosis·M WessmanS Knuutila
Aug 17, 2001·Clinical Chemistry and Laboratory Medicine : CCLM·F Torricelli, C Pescucci
Aug 1, 1978·Acta Pathologica Et Microbiologica Scandinavica. Section C, Immunology·S BjörkbomA de la Chapelle
Jan 1, 1979·Animal Blood Groups and Biochemical Genetics·M J Newman, H C Hines
Jan 1, 1977·Scandinavian Journal of Immunology·O TurunenA de la Chapelle
Jul 1, 1998·British Journal of Obstetrics and Gynaecology·W L MartinD T Liu

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