Transplacental passage of protease inhibitors at delivery

AIDS
Catia MarzoliniSwiss Mother + Child HIV Cohort Study

Abstract

Although combinations of different antiretroviral drugs are increasingly used by pregnant HIV-1-infected women, few human data are available to evaluate in utero protease inhibitors (PI) exposure. The aim of this study was to assess the extent of transplacental passage of PI at delivery. Pregnant women treated with antiretroviral drugs including PI and/or nevirapine were eligible for the study. Placental transfer was determined by comparison of drug concentrations in blood samples simultaneously collected from a peripheral maternal vein and the umbilical cord at delivery. Drug levels were determined by high-performance liquid chromatography. Thirteen maternal-cord blood sample pairs were evaluable for transplacental passage determination (nine nelfinavir, two ritonavir, one saquinavir, one lopinavir, two nevirapine). Median cord and maternal drug concentrations, respectively, were nelfinavir < 250 and 1110 ng/ml; ritonavir < 250 and 1113 ng/ml; saquinavir < 100 and 350 ng/ml; lopinavir < 250 and 3105 ng/ml and nevirapine 2072 and 2546 ng/ml. The cord-to-maternal blood ratio was extremely low for all PI. PI do not cross the placenta to an appreciable extent and consequently cannot be expected to exert a direct antiviral activity...Continue Reading

References

Mar 1, 1995·Clinical Pharmacokinetics·G M Pacifici, R Nottoli
Dec 10, 1997·Clinical Pharmacokinetics·R LoebsteinG Koren
Jan 1, 1997·AIDS·A ReggyM Rogers
Oct 3, 1998·American Journal of Obstetrics and Gynecology·B M Casey, R E Bawdon
Oct 9, 1999·Journal of Pharmaceutical Sciences·M Yazdanian
Nov 24, 1999·The Journal of Clinical Investigation·J W SmitA H Schinkel
Dec 29, 2000·Annals of the New York Academy of Sciences·M Mirochnick
Jan 11, 2001·Drugs·M Hurst, D Faulds
Jun 12, 2001·AIDS·UNKNOWN European Collaborative Study, UNKNOWN Swiss Mother and Child HIV Cohort Study

❮ Previous
Next ❯

Citations

Feb 14, 2013·Drugs·Nisha Andany, Mona R Loutfy
Jun 11, 2005·Early Human Development·Gian Maria Pacifici
Nov 19, 2003·Regulatory Toxicology and Pharmacology : RTP·Leigh Ann Burns-NaasMark Zorbas
Nov 19, 2003·Regulatory Toxicology and Pharmacology : RTP·Leigh Ann Burns-NaasMark Zorbas
Feb 28, 2004·Journal of Pharmacological and Toxicological Methods·P Myllynen, K Vähäkangas
Jun 22, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·C MarzoliniL A Decosterd
Jun 18, 2009·AIDS Patient Care and STDs·Silvia BaroncelliUNKNOWN Italian Group on Surveillance on Antiretroviral Treatment in Pregnancy
Mar 3, 2006·AIDS·Martin LecheltAnnemiek de Ruiter
Apr 18, 2009·Current Opinion in HIV and AIDS·Brookie M Best, Edmund V Capparelli
Mar 28, 2008·HIV Medicine·E V CapparelliUNKNOWN PACTG P1022 Study Team
May 26, 2006·Antimicrobial Agents and Chemotherapy·Déborah HirtSaïk Urien
Feb 25, 2005·Antimicrobial Agents and Chemotherapy·Sreeja SudhakaranCraig R Rayner
Jun 2, 2004·Clinical Pharmacokinetics·Michael R SymeJeffrey A Keelan
Dec 1, 2004·Clinical Pharmacokinetics·Mark Mirochnick, Edmund Capparelli
Sep 17, 2014·Clinical Pharmacokinetics·Shelley A McCormack, Brookie M Best
Mar 16, 2007·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Cornelia Feiterna-SperlingMichael Obladen
Oct 19, 2013·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Monica GandhiUNKNOWN Prevention of Malaria and HIV disease in Tororo (PROMOTE) study
Jul 2, 2004·Therapeutic Drug Monitoring·Natella Y RakhmaninaSteven J Soldin
Apr 24, 2014·Scandinavian Journal of Infectious Diseases·Lars NavérKarin Pettersson
Dec 5, 2008·Expert Review of Anti-infective Therapy·Robin Wood
Oct 16, 2004·Expert Review of Anti-infective Therapy·Marie-Louise Newell, Claire Thorne
Jan 21, 2015·Expert Opinion on Drug Metabolism & Toxicology·Frantisek Staud, Martina Ceckova
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Denis EvseenkoJeffrey A Keelan
Mar 9, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Claire Thorne, Marie-Louise Newell
Jun 1, 2011·Journal of Pharmaceutical Sciences·Masatoshi TomiEmi Nakashima
Dec 11, 2008·Journal of Pharmaceutical Sciences·Abhishek Gulati, Phillip M Gerk
Sep 24, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Laurent GavardSophie Gil
Jan 26, 2006·Basic & Clinical Pharmacology & Toxicology·Marika T GranforsJanne T Backman
Aug 29, 2006·British Journal of Clinical Pharmacology·P VillaniM Regazzi
Sep 20, 2006·British Journal of Clinical Pharmacology·Sreeja SudhakaranRoger L Nation
Mar 28, 2006·Reproductive Toxicology·Martina Ceckova-NovotnaFrantisek Staud
Apr 14, 2009·HIV Clinical Trials·Chantelle Bennetto-HoodEdward P Acosta
Mar 30, 2005·Expert Opinion on Drug Safety·Claire Thorne, Marie-Louise Newell
May 9, 2006·American Journal of Obstetrics and Gynecology·Laurent GavardLaurent Mandelbrot
Dec 8, 2014·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Meng WangPhillip M Gerk
Nov 4, 2016·Pharmaceutical Research·Anand A JoshiPhillip M Gerk
Aug 27, 2005·Mitochondrion·Lori E KamemotoMariana Gerschenson
Jan 15, 2004·Obstetrics and Gynecology Clinics of North America·Deborah M Money
Mar 4, 2009·International Journal of STD & AIDS·D RipamontiF Suter

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.