Transplacental toxoplasmosis in naturally-infected white-tailed deer: Isolation and genetic characterisation of Toxoplasma gondii from foetuses of different gestational ages

International Journal for Parasitology
J P DubeyC Su

Abstract

Clinical toxoplasmosis is most severe in congenitally-infected hosts. In humans, transmission of Toxoplasma gondii from the mother to the foetus is considered to be most efficient during the last trimester of pregnancy but clinical congenital toxoplasmosis is more severe if transmission occurs during the first trimester. However, there are no data on the rate of congenital transmission of T. gondii with respect to gestational age in any host during natural infection. In the present study, attempts were made to isolate T. gondii by bioassay in mice inoculated with tissues from foetuses of 88 naturally-exposed white-tailed deer from Iowa and Minnesota. Viable T. gondii was isolated from foetuses of six of 61 deer in early pregnancy (45-85 days of gestation) from Iowa and foetuses of nine of 27 deer from Minnesota in mid-gestation (130-150 days) of a gestational period of 7 months. The 15 T. gondii isolates obtained from foetal deer were PCR-restriction fragment length polymorphism genotyped using polymorphisms at 10 nuclear markers including SAG1, SAG2, SAG3, BTUB, GRA6, c22-8, c29-2, L358, PK1 and an apicoplast marker, Apico. Five genotypes were revealed, including the clonal Type II and III lineages, and three non-clonal genoty...Continue Reading

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Citations

Apr 14, 2011·Foodborne Pathogens and Disease·Beniamino T Cenci-GogaJames S Cullor
May 24, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey L Jones, J P Dubey
Feb 9, 2013·The Journal of Parasitology·Flaviana Santos WanderleyRinaldo Aparecido Mota
Jun 26, 2008·The Journal of Parasitology·A M A RagozoS M Gennari
Oct 18, 2008·The Journal of Parasitology·J P DubeyC Su
Dec 17, 2010·The Journal of Parasitology·Y M Al-KappanyJ P Dubey
Nov 17, 2015·Animal Health Research Reviews·Heidi M Wyrosdick, John J Schaefer
Aug 22, 2009·International Journal for Parasitology·D C HerrmannG Schares
Mar 5, 2008·Veterinary Parasitology·J A GamarraS Almeria
Jan 6, 2009·The Journal of Eukaryotic Microbiology·Jitender P Dubey
Feb 8, 2014·Journal of Wildlife Diseases·Rafael Calero-BernalIsabel Fuentes
Aug 10, 2011·Veterinary Parasitology·Jered M WendteMichael E Grigg
Jan 10, 2012·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·C RajendranJ P Dubey
May 18, 2016·The Korean Journal of Parasitology·Seon-Ju YeoHyun Park
May 12, 2009·Memórias do Instituto Oswaldo Cruz·J P Dubey, Chunlei Su
May 18, 2019·Parasitology Research·Karmen M Hollis-EtterRichard E Warner

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