Transplacental transfer of oseltamivir carboxylate

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
Tatiana N NanovskayaMahmoud S Ahmed

Abstract

Determine the bidirectional transfer of oseltamivir carboxylate (OC) across term human placenta and its distribution between the tissue, maternal and fetal circuits. The technique of dual perfusion of placental lobule (DPPL) in its recirculating mode was utilized to determine the transfer of the drug. OC (350 ng/mL) was co-perfused with its [(3)H]-isotope and the marker compound antipyrine (AP, 20 µg/mL) together with its [(14)C]-isotope. The concentrations of OC and any of its metabolite(s) formed during perfusion were determined in the tissue, maternal and fetal circuits by liquid scintillation spectrometry following their separation by High Performance Liquid Chromatography (HPLC). The distribution of OC following its perfusion in the Maternal-to-Fetal direction for 4 h was as follows: 21 ± 4% of the drug was transferred to the fetal circuit, 13 ± 5% was retained by the perfused lobule, and 66 ± 4% remained in the maternal circuit. The normalized transfer of OC to that of AP (Clearance index) in the maternal-to-fetal direction was (0.47 ± 0.11) and was not different from its transfer from the fetal-to-maternal direction (0.47 ± 0.06) suggesting that involvement of placental efflux transporters is unlikely. OC crosses human p...Continue Reading

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Citations

Oct 5, 2014·Seminars in Perinatology·Yang ZhaoRaman Venkataramanan
Oct 5, 2014·Seminars in Perinatology·Richard H BeigiSteve N Caritis
Feb 3, 2016·Journal of Neonatal-perinatal Medicine·L M GhulmiyyahA H Nassar
Jun 26, 2015·Clinical Pharmacology and Therapeutics·R H BeigiS N Caritis
Sep 28, 2013·American Journal of Obstetrics and Gynecology·Tatiana N NanovskayaMahmoud S Ahmed
Jul 19, 2016·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Hua HuangJun Zhang
Dec 20, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Timothy M UyekiAndrew T Pavia
Apr 23, 2021·American Journal of Obstetrics and Gynecology·Zhaoxia RenAaron C Pawlyk
Jul 1, 2021·Open Forum Infectious Diseases·Eric J ChowTimothy M Uyeki

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