Transplacental transmission of Bluetongue virus serotype 1 and serotype 8 in sheep: virological and pathological findings

PloS One
M T W van der SluijsA J de Smit

Abstract

The Bluetongue virus serotype 8 (BTV-8) strain, which emerged in Europe in 2006, had an unusually high ability to cause foetal infection in pregnant ruminants. Other serotypes of BTV had already been present in Europe for more than a decade, but transplacental transmission of these strains had never been demonstrated. To determine whether transplacental transmission is a unique feature of BTV-8 we compared the incidence and pathological consequences of transplacental transmission of BTV-8 to that of BTV-1. Nine pregnant ewes were infected with either BTV-8 or BTV-1. The BTV strains used for the infection were field strains isolated on embryonated chicken eggs and passaged twice on mammalian cells. Blood samples were taken to monitor the viraemia in the ewes. Four weeks after the infection, the foetuses were examined for pathological changes and for the presence of BTV. BTV-8 could be demonstrated in 12 foetuses (43%) from 5 ewes (56%). %). BTV-1 was detected in 14 foetuses (82%) from 6 ewes (67%). Pathological changes were mainly found in the central nervous system. In the BTV-8 group, lympho-histiocytic infiltrates, gliosis and slight vacuolation of the neuropil were found. BTV-1 infection induced a severe necrotizing encephal...Continue Reading

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Citations

Mar 22, 2014·Critical Reviews in Microbiology·Mirjam Tineke Willemijn van der SluijsRob J M Moormann
Jan 13, 2015·Transboundary and Emerging Diseases·P GaleE L Snary
May 16, 2019·Veterinary Research·Noémie CourtejoieBenoît Durand
Mar 8, 2017·EFSA Journal·UNKNOWN EFSA Panel on Animal Health and Welfare
Feb 7, 2021·Pathogens·Labrini V AthanasiouPanagiotis D Katsoulos
Nov 28, 2021·Pathogens·José M RojasNoemí Sevilla

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

CFX96

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