Transplant outcomes in acute leukemia. I.

Seminars in Hematology
Mary Eapen, John E Wagner

Abstract

Umbilical cord blood (UCB) has gradually emerged over the last decade as an alternative source of hematopoietic cells for transplantation in children and adults with high-risk or advanced hematologic malignancies who do not have a suitably matched related or unrelated adult donor. This increase in use of UCB is due to favorable results in children, growing availability of UCB units with large cell doses, less stringent donor-recipient HLA matching, and rapid identification and acquisition of the unit. In children with acute leukemia, the data support similar leukemia-free survival after transplantation of human leukocyte antigen (HLA)-matched and one or two HLA-mismatched UCB and HLA-matched unrelated donor bone marrow. In adults with acute leukemia, some reports suggest a survival advantage after transplantation of matched unrelated bone marrow compared to UCB, while others report similar leukemia-free survival. Work is in progress to improve hematopoietic recovery and lower early transplant-related deaths, the two major limitations to a successful outcome after UCB transplant. The importance of HLA-matching and cell dose on outcomes after UCB transplantation support the need for an even greater investment in public cord blood...Continue Reading

References

Nov 27, 2004·The New England Journal of Medicine·Mary J LaughlinMary M Horowitz
Aug 9, 2006·Current Opinion in Immunology·Eliane Gluckman, Vanderson Rocha
Nov 21, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Mary EapenClaudio Anasetti

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Citations

Jan 18, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Camino Latorre-RomeroPilar Martin-Duque
May 30, 2013·The American Journal of Surgical Pathology·Nitin K Gupta, Ricard Masia
Apr 2, 2010·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Paolo Rebulla
Dec 10, 2019·Current Opinion in Pediatrics·Caitlin W Elgarten, Richard Aplenc

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