Transplant tolerance: models, concepts and facts

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Nicola J MonkStipo Jurcevic

Abstract

Despite extensive research, our understanding of immunological tolerance to self-antigens is incomplete, and the goal of achieving tolerance to allogeneic transplanted tissue remains elusive. Currently, it is generally believed that the blockade of T cell co-stimulation offers considerable potential for achieving tolerance in the clinical setting. However, the recent finding that CD154-specific antibody may act through the depletion of activated T cells rather than co-stimulation blockade alone highlights the need for a re-evaluation of published data and the role of co-stimulation blockade in transplant tolerance. Activated T cells are programmed to die unless they receive sufficient survival signals in the form of inflammatory and lymphotropic cytokines produced by activated antigen-presenting cells or the T cells themselves. In conditions where the threshold for surviving activation is not reached, for example when a small number of responder T cells are activated in the absence of substantial injury or inflammation, the ensuing death of all activated T cells can result in deletional tolerance. Therefore, we propose that tolerance represents a failure of T cells to survive activation and develop into memory cells. This conce...Continue Reading

References

Apr 1, 1989·Transplant International : Official Journal of the European Society for Organ Transplantation·S M Lim, D J White
Jan 1, 1989·Cold Spring Harbor Symposia on Quantitative Biology·C A Janeway
Sep 11, 1970·Science·P Bretscher, M Cohn
Apr 19, 1984·Nature·R Schwartz
Jan 1, 1994·Annual Review of Immunology·P Matzinger
May 1, 1993·Immunology Today·R E Langman, M Cohn
Aug 5, 1997·Proceedings of the National Academy of Sciences of the United States of America·A D KirkS J Knechtle
Feb 5, 1999·European Journal of Immunology·J Mysliwietz, S Thierfelder
Feb 17, 1999·The Journal of Experimental Medicine·F Sallusto, A Lanzavecchia
Aug 24, 1999·Current Opinion in Nephrology and Hypertension·W W Hancock
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·C KurtsW R Heath
Dec 22, 1999·The Journal of Clinical Investigation·J TrambleyC P Larsen
Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A J AdlerD M Pardoll
Feb 2, 2000·Nature Medicine·V R DharnidharkaS Skoda-Smith
Mar 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A W BingamanC P Larsen
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A WilliamsC P Larsen
Jul 14, 2001·Science·R M Zinkernagel, H Hengartner
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K A FrauwirthC B Thompson
Mar 23, 2002·Nature Reviews. Immunology·Lucy S K Walker, Abul K Abbas
Jun 5, 2002·The Journal of Clinical Investigation·Koji KishimotoMohamed H Sayegh
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anna ValujskikhPeter S Heeger
Jul 18, 2002·The Journal of Experimental Medicine·Kevin L LeggeHabib Zaghouani
Aug 16, 2002·Transplant Immunology·Alice A BickerstaffCharles G Orosz
Aug 23, 2002·Immunological Reviews·Jonathan Sprent, Hidehiro Kishimoto
Aug 30, 2002·Trends in Immunology·Manfred B Lutz, Gerold Schuler
Sep 3, 2002·Nature Immunology·Hans Dooms, Abul K Abbas
Sep 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masayuki ShoMohamed H Sayegh
Nov 5, 2002·Current Opinion in Immunology·Pamela S Ohashi, Anthony L DeFranco
Nov 5, 2002·Nature Reviews. Immunology·Annette R Khaled, Scott K Durum
Dec 10, 2002·Annual Review of Immunology·Ronald H Schwartz
Mar 28, 2003·Nature Immunology·Jonathan Sprent, Charles D Surh
Apr 19, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ching-Tai HuangAdam J Adler
Oct 2, 2003·Nature Medicine·Herman Waldmann

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Citations

Nov 26, 2009·Science in China. Series C, Life Sciences·ZhangFei ShouJiangHua Chen
Nov 26, 2008·Clinics in Laboratory Medicine·Persis P Wadia, Anat R Tambur
Aug 5, 2008·Transplantation Proceedings·M BerlandaG Orlando
Dec 22, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Marie KingDale L Greiner
Sep 13, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R E GreenlawS Jurcevic
Apr 13, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B M WeistC M Walsh
Apr 9, 2015·Transplant International : Official Journal of the European Society for Organ Transplantation·Daniel BaronSophie Brouard
Oct 13, 2017·Journal of Medicinal Chemistry·Jinshui ChenPeter Buchwald

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