PMID: 7547552Jan 1, 1994Paper

Transplantation 1994: the year in review

Clinical Transplants
B J Browne, B D Kahan

Abstract

Progress during 1994 has yielded important positive effects on the clinical practice of transplantation. During the span of one generation, organ transplantation has moved from an experimental endeavor to an established therapeutic modality. Technical advances have improved the safety of the surgical enterprise, such that the major focus of research is now immunosuppressive therapy. Although tacrolimus has been approved for use in liver transplantation, ongoing trials seek to establish its role in the immunosuppressive arsenal. Undoubtedly, the introduction of mycophenolate mofetil and Neoral in the coming year, and probably sirolimus shortly thereafter, will broaden the spectrum of immunosuppressive agents, thereby improving transplant results. The recently completed multicenter studies not only demonstrated effective cooperative efforts by the transplant community, but also offered new insights into the more efficient design of future clinical trials. Although rejection remains the major barrier to transplant success, increasingly it is recognized that improved outcomes demand a decreased spectrum of iatrogenic side effects that markedly increase morbidity. Thus, strides in immunosuppressive management must be evaluated both ...Continue Reading

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