PMID: 11604571Oct 18, 2001Paper

Transplantation hematopoiesis

Current Opinion in Hematology
M Podestà

Abstract

Hematopoietic reconstitution after transplantation relies on a small number of hematopoietic stem cells that selectively migrate from the bloodstream to the hematopoietic microenvironment. In the first phase of engraftment, an extreme proliferative demand causes a limited stem cell fraction and its progeny to divide continuously, showing a significant telomere shortening. When all hematopoietic compartments are fully reconstituted, progenitor cell replication stabilizes and the stem cell pool reverts to a quiescent state. In transplant recipients, the hematopoietic microenvironment and stem cell reservoir remain defective for a prolonged period. However, in most patients donor-derived polyclonal hemopoiesis results, and the system is not exhausted but is capable of sustained normal counts and eventually overcomes stressed conditions.

References

Mar 1, 1991·Mutation Research·C B Harley
May 31, 1990·Nature·C B HarleyC W Greider
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J MeyneR K Moyzis
Sep 1, 1995·Experimental Cell Research·R C AllsoppC B Harley
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·J L AbkowitzP Guttorp
Mar 1, 1994·The Journal of Clinical Investigation·E D ZanjaniM Tavassoli
Feb 1, 1996·Nature Medicine·J L AbkowitzP Guttorp
Jun 1, 1996·The Journal of Experimental Medicine·N P WengR J Hodes
May 1, 1997·Bone Marrow Transplantation·M PodestàA Bacigalupo
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·R NotaroL Luzzatto
Jul 22, 1998·The Journal of Experimental Medicine·H K HabibianP J Quesenberry
Oct 8, 1998·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·E J ShpallJ A Glaspy
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·S H CheshierI L Weissman
May 26, 1999·Experimental Hematology·D S DonnellyD S Krause
Jun 18, 1999·Annals of the New York Academy of Sciences·S M LanzkronS J Sharkis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.