Transplantation in the single ventricle population

Annals of Cardiothoracic Surgery
Louise A KennyAsif Hasan

Abstract

The single ventricle patient population comprises the most complex cohort presenting to the cardiac transplant team, in terms of demographics, anatomic substrate, and unique physiology. It is also the most rapidly growing diagnostic group presenting for heart transplantation. In this manuscript, we aim to describe the changing landscape of transplantation in single ventricle conditions through reflection on our own institution's practice and experience, alongside contemporary literature review. Single ventricle patients are heterogeneous in terms of age, anatomic diagnosis and physiology according to surgical stage of repair. Progress in surgical palliative strategies has impacted upon the present composition of the population, with growing numbers of hypoplastic left heart syndrome patients and those with late physiology failure following Fontan completion. Multiple prior surgeries, immunological sensitivity and multi-organ involvement impart high peri-operative risk but can be mitigated in part by careful pre-operative planning by a dedicated multi-disciplinary team addressing issues such as planning of concurrent reconstructive surgery, minimizing the post-operative effect of collaterals, timely harvesting, oversizing of don...Continue Reading

Citations

Dec 24, 2018·Current Opinion in Cardiology·Shuhua Luo, Osami Honjo
Feb 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anastacia M GarciaStephanie J Nakano
May 31, 2020·Heart Failure Reviews·James MonacoPrateeti Khazanie
Jul 11, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Ray S ChoiMorgan L Brown
Aug 11, 2018·Current Cardiology Reports·John D SerfasRichard A Krasuski
Dec 16, 2019·JACC. Heart Failure·Jonathan N MenachemJoAnn Lindenfeld
Jun 20, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Thomas G CotterMichael Charlton
May 5, 2021·World Journal for Pediatric & Congenital Heart Surgery·Kyle W RiggsDavid L S Morales
Mar 31, 2020·The Journal of Thoracic and Cardiovascular Surgery·Daniel E ClarkJonathan N Menachem
Apr 22, 2019·The Journal of Thoracic and Cardiovascular Surgery·W C Patrick LinCristina H Amon

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