Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

Journal of Hepatology
Yasuhito NagamotoHiroyuki Mizuguchi

Abstract

Hepatocyte transplantation is one of the most attractive approaches for the treatment of patients with liver failure. Because human induced pluripotent stem cell-derived hepatocyte-like cells (iPS-HLCs) can be produced on a large scale and generated from a patient with liver failure, they are expected to be used for hepatocyte transplantation. However, when using conventional transplantation methods, i.e., intrasplenic or portal venous infusion, it is difficult to control the engraftment efficiency and avoid unexpected engraftment in other organs because the transplanted cells are delivered into blood circulation before their liver engraftment. In this study, to resolve these issues, we attempted to employ a cell sheet engineering technology for experimental hepatocyte transplantation. The human iPS-HLC sheets were attached onto the liver surfaces of mice with liver injury. This method reduced unexpected engraftment in organs other than the liver compared to that by intrasplenic transplantation. Human albumin levels in the mice with human iPS-HLC sheets were significantly higher than those in the intrasplenically-transplanted mice, suggesting the high potential for cell engraftment of the sheet transplantation procedure. In add...Continue Reading

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Citations

May 5, 2016·Expert Review of Gastroenterology & Hepatology·Yu Wang, David C Hay
Aug 10, 2016·Stem Cells and Development·Sharmila FagooneeFiorella Altruda
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