Transplantation of adipose tissue-derived stem cells improves cardiac contractile function and electrical stability in a rat myocardial infarction model

Journal of Molecular and Cellular Cardiology
Milan GautamYuji Shiba

Abstract

The transplantation of adipose tissue-derived stem cells (ADSCs) improves cardiac contractility after myocardial infarction (MI); however, little is known about the electrophysiological consequences of transplantation. The purpose of this study was to clarify whether the transplantation of ADSCs increases or decreases the incidence of ventricular tachyarrhythmias (VT) in a rat model of MI. MI was induced experimentally by permanent occlusion of the left anterior descending artery of Lewis rats. ADSCs were harvested from GFP-transgenic rats, and were cultured until passage four. ADSCs (10×10(6)) resuspended in 100μL saline or pro-survival cocktail (PSC), which enhances cardiac graft survival, were injected directly into syngeneic rat hearts 1week after MI. The recipients of ADSCs suspended in PSC had a larger graft area compared with those receiving ASDCs suspended in saline at 1week post-transplantation (number of graft cells/section: 148.7±10.6 vs. 22.4±3.4, p<0.05, n=5/group). Thereafter, all ADSC recipients were transplanted with ASDCs in PSC. ADSCs were transplanted into infarcted hearts, and the mechanical and electrophysiological functions were assessed. Echocardiography revealed that ADSC recipients had improved contract...Continue Reading

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Citations

Oct 16, 2015·Journal of Biomedical Materials Research. Part a·Mojtaba ParviziMartin C Harmsen
Oct 21, 2015·Frontiers in Cell and Developmental Biology·Amanda Finan, Sylvain Richard
Nov 8, 2016·Stem Cells International·Joshua T MaxwellMichael E Davis
Feb 27, 2018·Journal of Cellular and Molecular Medicine·Ludovic MellyAndrea Banfi
May 2, 2020·Journal of Clinical Medicine·Ming-Long ChangHsiu-Hu Lin
Jun 13, 2017·Circulation Journal : Official Journal of the Japanese Circulation Society·Hajime Ichimura, Yuji Shiba
Feb 14, 2017·Stem Cells Translational Medicine·Carolina Gálvez-MontónAntoni Bayes-Genis
Jul 23, 2020·Molecular Therapy. Methods & Clinical Development·Alice RannouLaetitia Guével

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