Transplantation of autologous peripheral blood progenitor cells: impact of CD34-cell selection on immunological reconstitution

Leukemia & Lymphoma
S RutellaG Leone

Abstract

Peripheral blood progenitor cells (PBPC) represent an ideal source of stem cells for autologous transplantation because of technical advantages and more favourable engraftment kinetics. The reconstituion of a functional immune system occurs earlier in patients transplanted with cytokine-mobilized autologous PBPC compared with bone marrow; because of the greater T-cell content in PBPC products, donor-derived antigen-specific T-cells transferred with the graft might contribute to short-term immunity in transplant recipients. Despite a prompt reconstitution of B- and T-cell numbers, both B- and T-cell function are profoundly impaired for a prolonged period of time after PBPC infusion. The positive selection of CD34+ cells might provide effective tumor cell purging without compromising hematopoietic recovery in patients with acute leukemia, multiple myeloma, breast cancer and non-Hodgkin's lymphoma, whose autografts have been reported to contain malignant cells which might promote disease relapse. However, the incidence of viral infections in the early posttransplant period might be increased after CD34-selected compared with unmanipulated PBPC transplants, as a result of the lack of accessory and immune cells in the graft. The pur...Continue Reading

Citations

Jan 14, 2005·International Journal of Hematology·Hisashi GondoMine Harada
Mar 22, 2005·Bone Marrow Transplantation·J J Auletta, H M Lazarus
Apr 10, 2010·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huiying LuoXuan Chen
Jul 4, 2007·Transplant Infectious Disease : an Official Journal of the Transplantation Society·A Grigg, M Slavin
Jan 13, 2006·European Journal of Haematology·Pascale FrèreYves Beguin
Jun 19, 2004·Cytotherapy·C J TurtleD N J Hart

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