Transplantation of azaserine-induced carcinomas of pancreas in rats

Cancer Letters
D S LongneckerW Noll

Abstract

Two pancreatic adenocarcinomas which had been induced in Wistar/Lewis rats by azaserine treatment were transplanted into rats of the same strain by subcutaneous and intraperitoneal injection of minced tumor. Subsequently, we have serially transplanted into non-radiated recipients. Transplanted tumors have maintained evidence of acinar cell differentiation including the presence of zymogen granules in tumors studied by electron microscopy, and of lipase, amylase and trypsin activity in the supernatant of tumor homogenates. Histologically, the tumors vary from poorly differentiated solid carcinomas to well differentiated variants which form acini. Transplanted tumors are locally invasive and have metastasized to lung and liver in some recipients.

References

Oct 7, 1977·Science·J K Reddy, M S Rao

Citations

Dec 18, 2001·International Journal of Cancer. Journal International Du Cancer·J S LewisC J Anderson
Jan 1, 1995·Lasers in Surgery and Medicine·K T MoestaT S Mang
Jan 1, 1985·Experimental Pathology·M S Rao, J K Reddy
Sep 21, 2002·Molecular and Cellular Endocrinology·Eva HofsliAstrid Laegreid
Apr 27, 2001·Nuclear Medicine and Biology·J E BugajA Srinivasan
Jun 26, 1999·Nuclear Medicine and Biology·D W McCarthyM J Welch
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T W Redding, A V Schally
Feb 21, 2002·Pancreas·Alexis B UlrichParviz M Pour
May 11, 2012·Neuroendocrinology·Eva Forssell-AronssonHåkan Ahlman
Jun 1, 1984·Environmental Health Perspectives·G A Boorman, S L Eustis
Dec 7, 2013·PloS One·Ersin AkinciJonathan M W Slack
Jun 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jessy LardonLuc Bouwens
Feb 18, 2011·Physiology & Behavior·Maik Behrens, Wolfgang Meyerhof
Aug 18, 2004·Biochemical and Biophysical Research Communications·Su YuA W Lowe
Sep 6, 2005·Differentiation; Research in Biological Diversity·Jessy Lardon, Luc Bouwens
Dec 14, 2011·The Biochemical Journal·Ersin AkinciJonathan M W Slack
Oct 1, 2004·Organogenesis·Chia Ning ShenDavid Tosh
Dec 20, 2002·Mechanisms of Development·Chia Ning ShenDavid Tosh
Feb 18, 2010·Expert Opinion on Drug Discovery·Georg FeldmannAnirban Maitra
Feb 24, 2001·Cancer Biotherapy & Radiopharmaceuticals·J S LewisC J Anderson
Mar 15, 1981·Cancer·J R Warren, J K Reddy
Jan 9, 2001·Nature Cell Biology·C N ShenD Tosh
Apr 15, 1985·International Journal of Cancer. Journal International Du Cancer·G TatonG G Poirier
Aug 4, 1998·The American Journal of Physiology·Y ZhuR P Rubin
Jul 30, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Chhanda BoseParimal Chowdhury
Jan 1, 1990·Molecular Carcinogenesis·B K SchaefferD S Longnecker
Dec 15, 2006·World Journal of Gastroenterology : WJG·Parimal Chowdhury, Kodetthoor-B Udupa
Jul 25, 2015·Chemistry : a European Journal·Damien LhenryFranck Denat
Mar 16, 2005·Clinical Science·Zoë D Burke, David Tosh

Related Concepts

Carcinoma, Cribriform
Metazoa
LL-D05139a
Neoplasm Transplantation
Neoplasms, Experimental
Malignant Neoplasm of Pancreas
Transplantation, Homologous
Rats, Laboratory

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.