Transplantation of Center for Disease Control "High-Risk" Donor Hearts Does Not Adversely Impact Long-Term Outcomes in Adults

Journal of Cardiac Failure
Ann C GaffeyPavan Atluri

Abstract

The "high-risk donor" (HRD) label was applied to donors who met the Centers for Disease Control and Prevention criteria for high-risk behavior in 2004. The number of potential recipients who die awaiting orthotopic heart transplantation (OHT) has increased. Despite organ shortages, HRD grafts are often declined given infectious concerns. We hypothesized that recipients would have equivalent outcomes. We retrospectively analyzed the United Network of Organ Sharing adult heart transplant data from June 2004 to December 2013. OHT recipients were divided into 2 cohorts by donor status. During the study period, 37,408 OHTs were performed and 3196 (8.5%) patients received HRD grafts. Recipients of HRD were significantly older (P < .0001) and had a higher body mass index (P < .0001) compared with standard-risk donor recipients. No significant difference in waitlist time (P = .69) or blood type (P = .07) was noted. A higher number of HRD recipients were on mechanical circulatory support (35.6%) compared with standard-risk donor (33.3%, P = .009). Both grafts manifested similar, low rates of rejection before discharge (P = .88). One1 (84.3 vs 83%) and 5-year (71.2 vs 65.5%) survival was similar in the cohorts (log-rank P = .7571). HRD s...Continue Reading

Citations

Sep 22, 2019·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Ethan MarkJoel Sokol
Oct 6, 2017·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Arnaud G L'HuillierDeepali Kumar
Oct 24, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Paolo Antonio GrossiAlessandro Nanni Costa
Dec 26, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Sarah J KizilbashBlanche M Chavers
Jan 24, 2019·The Journal of Thoracic and Cardiovascular Surgery·Yasuhiro ShudoY Joseph Woo
Feb 24, 2016·The Journal of Thoracic and Cardiovascular Surgery·Ann C GaffeyPavan Atluri
Jan 12, 2020·The Journal of Thoracic and Cardiovascular Surgery·Carli J LehrMaryam Valapour
Jul 10, 2021·Journal of the American Heart Association·Geoffrey D HuntleyAri M Cedars

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