PMID: 9418974Jan 7, 1998Paper

Transplantation of CG4 oligodendrocyte progenitor cells in the myelin-deficient rat brain results in myelination of axons and enhanced oligodendroglial markers

Journal of Neuroscience Research
A Espinosa de los MonterosJ de Vellis

Abstract

Transplantation of oligodendrocyte (Ol) progenitor cells into the central nervous system is a promising approach for the treatment of myelin disorders. This approach requires providing adequate numbers of healthy cells with myelinating potential. We recently showed the successful transplantation of Ol progenitors into the myelin-deficient (md) rat brain. In the present work, CG4 cells, a cell line with properties of Ol progenitors, were labeled with fast blue and grafted into P3-P5 pups born to carrier mothers. Examination of host brains 2 weeks posttransplant indicated that CG4 cells display a much more extensive migration capacity than their wild-type counterparts. These cells synthesized myelin components. In addition, ultrastructural analysis showed myelin formation along axons of md hosts in various brain regions, including corpus callosum, cerebellum, and brainstem. Furthermore, in situ hybridization studies performed on sagittal sections revealed extensive expression of transferrin-mRNA within the md host parenchyma. The high survival and functional features displayed by CG4 cells after transplantation, together with their striking wide distribution within the host parenchyma, as assessed by the presence of myelinated fi...Continue Reading

References

Jan 1, 1992·Developmental Neuroscience·A Espinosa de los MonterosJ de Vellis
Dec 1, 1992·Acta Neurologica Scandinavica·S PoserK Felgenhauer
Sep 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D Pham-DinhA Dautigny
Jan 1, 1990·Progress in Neurobiology·P J Harrison, R C Pearson
Jan 1, 1990·Annals of the New York Academy of Sciences·I D Duncan
Oct 1, 1993·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A Espinosa de los MonterosJ de Vellis
Jul 1, 1993·Mayo Clinic Proceedings·M RodriguezP J Kelly
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·A Espinosa de los MonterosJ De Vellis
Feb 1, 1993·Annals of Neurology·J W PrineasE S Cho
Jan 7, 1998·Journal of Neuroscience Research·R J Franklin, S C Barnett

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Citations

May 12, 2010·Regenerative Medicine·Kevin KempAlastair Wilkins
May 3, 2008·Chemical Reviews·Heather E Murrey, Linda C Hsieh-Wilson
Mar 21, 2009·Journal of Neuroscience Research·Seung U Kim, Jean de Vellis
Aug 4, 2001·Toxicology and Applied Pharmacology·W DengR D Poretz
Sep 3, 2002·Journal of Neuroscience Research·Araceli Espinosa-JeffreyJean de Vellis
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·P F Smith, C L Darlington
Mar 29, 2001·Microscopy Research and Technique·A E De Los MonterosJ De Vellis
Feb 28, 2001·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·S WoerlyA Espinosa
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Jaime Imitola
May 20, 2020·Frontiers in Psychiatry·Yongbo ZhangZheng Zachory Wei
Feb 28, 2003·Neurotoxicology·Wenbin Deng, Ronald D Poretz

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