Transplantation of cryopreserved and fresh rat islets and canine pancreatic fragments: comparison of cryopreservation protocols

Cryobiology
R V RajotteA W Procyshyn

Abstract

(1) The freezing protocol we have devised for rat islets results in normal clinical indices and almost normal glucose tolerance in diabetic recipients of the same inbred strain. (2) Cryopreservation of canine islet-containing pancreatic tissue required a higher temperature than rat islets during exposure to the protective agent. (3) Because of the similar compactness of the pancreas in man and dog, we consider this canine model useful for formulating optimal cryopreservation techniques for the human pancreas. (4) Cryopreservation may partially purify islet-containing tissue of its exocrine content.

References

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Citations

Jan 1, 1993·Transplant International : Official Journal of the European Society for Organ Transplantation·J ForemanM J Taylor
Apr 1, 1984·World Journal of Surgery·R V RajotteN N Kneteman
Jun 1, 1986·World Journal of Surgery·D W Gray, P J Morris
Jun 1, 1997·Transplantation Proceedings·G S KorbuttR V Rajotte
Jan 1, 1991·Diabetic Medicine : a Journal of the British Diabetic Association·K FederlinB J Hering
Jul 23, 1999·Annals of the New York Academy of Sciences·R V Rajotte
Sep 23, 1997·Cryobiology·E J WoodsJ K Critser
Apr 1, 1991·Cryobiology·R FisherK Brendel
Oct 1, 1985·The Journal of Surgical Research·N M KnetemanA W Procyshyn
Apr 28, 2009·The Journal of Surgical Research·Tormod LundAksel Foss
Nov 12, 2016·Nature Reviews. Endocrinology·A M James ShapiroCamillo Ricordi
Jul 31, 2018·Frontiers in Medicine·Rita BottinoMassimo M Trucco

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