PMID: 15222801Jun 30, 2004Paper

Transplantation of dermal multipotent cells promotes survival and wound healing in rats with combined radiation and wound injury

Radiation Research
Chunmeng ShiChengji Luo

Abstract

Combined radiation and wound injury occurs after severe nuclear accidents that accompany explosions or nuclear attacks. High doses of ionizing radiation can cause bone marrow aplasia and delay wound healing. Combined radiation and wound injury is very complex and is more difficult to deal with than single injuries. Multipotent stem cells that have self-renewal potential and multilineage differentiation capacity are the relevant cells in regenerative medicine. To determine whether multipotent stem cells can have multiple therapeutic effects in vivo, systemic transplantation of cultured dermal multipotent cells was performed in rats with combined radiation and wound injury. The results showed that dermal multipotent cell transplantation promoted survival and accelerated both hematopoietic recovery and wound healing in rats with combined radiation and wound injury. FISH analysis using a Y-chromosome-specific probe indicated that donor dermal multipotent cells could engraft into recipient skin and bone marrow after transplantation. FACS analysis of the proportions of CD2- and CD25-positive peripheral lymphocytes indicated that dermal multipotent cell transplantation did not induce an obvious activation of allogeneic lymphocytes in ...Continue Reading

References

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May 30, 2001·Trends in Molecular Medicine·A I Caplan, S P Bruder
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Feb 2, 2002·Experimental Hematology·Amelia BartholomewRonald Hoffman
Nov 26, 2002·Trends in Cell Biology·Catherine M Verfaillie
Jan 7, 2004·Cells, Tissues, Organs·Chunmeng Shi, Tianmin Cheng
Jun 30, 2004·International Journal of Radiation Biology·G C JagetiaP Kumar

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Citations

Apr 15, 2004·Medical Hypotheses·Shi Chunmeng, Cheng Tianmin
Jul 3, 2008·International Wound Journal·David S KwonSubhash C Gautam
Aug 31, 2006·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kellie McFarlinSubhash C Gautam
Nov 22, 2005·Trends in Biotechnology·Chunmeng ShiTianmin Cheng
Sep 17, 2011·The International Journal of Lower Extremity Wounds·Chunmeng Shi, Shuliang Lu
Jun 28, 2014·Cell Transplantation·Zelin ChenChunmeng Shi
May 23, 2008·Radiation Research·Zhongmin ZouChengji Luo
Mar 4, 2020·Journal of Materials Science. Materials in Medicine·Xiaoliang ChenZhiping Peng
Oct 6, 2010·Journal of Radiation Research·Zhao-Wen ZongTian-Min Cheng
Mar 25, 2017·Journal of Radiation Research·Elizabeth A McCartRegina M Day

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