Transplantation of human neural precursor cells in the 6-OHDA lesioned rats: effect of immunosuppression with cyclosporine A

Parkinsonism & Related Disorders
Sigrid C SchwarzJohannes Schwarz

Abstract

Neural precursor cells (NPC) may provide a source for restaurative therapy. We wanted to study the immunogenic potential of human NPC. We transplanted human NPCs with or without cyclosporine A (10 mg/kg) expanded in serum-free conditions into the striatum of rats unilaterally lesioned with 6-hydroxydopamine. Four months after transplantation, there was significant improvement of amphetamine-induced rotational behavior 9 non-immunosuppressed (13.1+/-4.9 pre vs 8.5+/-4.0 after grafting) but nor for 11 animals immunosuppressed with CyA (12.3+/-1.7 vs 11.3+/-2.8). The number of TH-IR cells was comparable in both groups (1,580+/-700 vs 1,274+/-295). All grafted animals only showed mild activation of astrocytes and macrophages within the graft. There was no evidence for tumor formation. Immunosuppression of rats, xenotransplanted with human NPC did not improve graft survival or function.

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Citations

Mar 26, 2011·Journal of Neurology·Kai Loewenbrück, Alexander Storch
Nov 24, 2007·Cell and Tissue Research·Asuka MorizanePatrik Brundin
Aug 2, 2008·Brain : a Journal of Neurology·Rosario Sanchez-PernauteOle Isacson
Jul 3, 2013·Pharmacological Reviews·George J ChristKarl-Erik Andersson
Sep 8, 2009·Journal of the Neurological Sciences·Anne K MeyerAlexander Storch
Jun 21, 2008·Biochemical and Biophysical Research Communications·Ravindran GeetaViswanathan Chandra
Nov 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Almut FockeJohannes Schwarz
May 18, 2010·Biochimica Et Biophysica Acta·Yannic WaerzeggersAndreas H Jacobs
Nov 15, 2008·Biochimica Et Biophysica Acta·Ruwani Wijeyekoon, Roger A Barker
Sep 5, 2013·Experimental Cell Research·Marco SkardellyJavorina Milosevic
Dec 25, 2012·Expert Review of Anticancer Therapy·Pierre-Antoine DuguéElsebeth Lynge

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