PMID: 11903388Mar 21, 2002Paper

Transplantation of livers from hbc Ab positive donors into HBc Ab negative recipients: a strategy and preliminary results

Clinical Transplantation
George E LossJ D Eason

Abstract

Here we describe a strategy for using livers from hepatitis B core antibody (anti-HBc) positive donors in anti-HBc negative recipients and report our preliminary results. Adult anti-HBc negative recipients were immunized against hepatitis B virus (HBV) prior to transplantation. Liver biopsies from anti-HBc positive, HBs Ag negative donors were performed at the time of procurement to rule out acute hepatitis or chronic liver disease. Donor serum and liver samples were collected for HBV DNA analysis by PCR. Recipients were given HBIG (10000 units, i.v.) during the anhepatic phase of transplantation. Patients were treated with lamivudine (150 mg) beginning on postoperative day (POD) 1. If HBV DNA was not detected in either donor liver or serum by PCR, recipient antiviral therapy was stopped. If donor liver and serum were positive for HBV DNA by PCR, the recipient was maintained on combination lamivudine and HBIG therapy. If HBV DNA was detected in donor liver but not in donor serum, the patient was managed on lamivudine therapy alone. Between February 1999 and June 2000, six anti-HBc negative recipients received liver transplants from anti-HBc positive donors. PCR analysis of serum from the six donors was negative for HBV DNA in e...Continue Reading

References

Jun 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L MasonR P Perrillo
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Citations

Sep 2, 2003·Transplantation Proceedings·P AndreoneM Bernardi
Feb 18, 2003·Transplantation·Vanessa H de VillaChao-Long Chen
Mar 21, 2012·Transplantation·Helen L Pilmore, Edward J Gane
Sep 7, 2007·Digestive Diseases and Sciences·Nobuyuki TakemuraMasatoshi Makuuchi
Jul 16, 2008·Clinics in Liver Disease·Elizabeth C Verna, Robert S Brown
Oct 1, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Martín Prieto
Jul 19, 2003·Clinical Transplantation·Antonio López-Navidad, Francisco Caballero
Dec 14, 2005·Liver International : Official Journal of the International Association for the Study of the Liver·Taketoshi SuehiroHiroyuki Kuwano
Mar 26, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Humberto E BohorquezGeorge E Loss
Oct 7, 2004·Journal of Hepatology·Juan Fernando Gallegos-OrozcoJorge Rakela
Aug 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emilio FábregaFernando Pons-Romero
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sammy SaabRonald W Busuttil
Nov 20, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·George E LossJames D Eason
Mar 16, 2011·Transplant International : Official Journal of the European Society for Organ Transplantation·Guy N BrockMichael R Marvin

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