PMID: 3756524Sep 24, 1986Paper

Transplantation of septal neurons maintained in long-term culture

Brain Research
R B GibbsC W Cotman

Abstract

Septal cells were maintained in culture for varying lengths of time and then transplanted to adult hippocampi from which the native septal input had been removed. Cells grafted after 1 week in culture survived transplantation to the brain and innervated the host hippocampus in a pattern comparable to the native cholinergic projection. Cells grafted after 2 weeks in culture did not survive in the brain, but did survive re-plating. In addition, the viability of cells transplanted from culture paralleled the viability of brain tissue taken from donors of equivalent ages, suggesting that changes which occur in culture and affect the viability of transplanted neurons may also occur during normal development.

References

Dec 1, 1979·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·L A Sternberger
Mar 1, 1983·The Journal of Cell Biology·P LiesiA Vaheri
Sep 21, 1984·Science·C W Cotman, M Nieto-Sampedro
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·Y A BardeH Thoenen
May 1, 1980·Brain Research Bulletin·E R LewisC W Cotman

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Citations

Mar 1, 1987·Brain Research Bulletin·E B Ezerman, L F Kromer
Jan 1, 1987·Journal of Neuroscience Research·S K PixleyC W Cotman

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