Transplantation of vascularized allogeneic skeletal muscle for scalp reconstruction in a renal transplant patient

Transplantation
T R JonesD C Brennan

Abstract

We report the case of a vascularized allogeneic skeletal muscle transplant (VASM) and autologous skin grafting as rescue therapy for refractory squamous cell carcinoma of the scalp. A renal transplant recipient with recurrent squamous carcinoma of the scalp underwent an excision that resulted in a 11 x 14 cm2 scalp defect with exposed cranium. At the time of multiorgan procurement, a section of rectus abdominis and external oblique muscle and fascia with its independent vascular bundle was isolated and stored in cold University of Wisconsin solution. The patient received methylprednisolone and rabbit antithymocyte globulin intravenously during scalp preparation, before single-vessel anastomosis of the deep inferior epigastric vascular bundle from the donor muscle to the recipient neck vessels. An autologous split-thickness skin graft was secured to the surface of the allogeneic muscle. Immunosuppression was maintained with prednisone and cyclosporine. Serial VASM biopsies were used to evaluate acute rejection. Perivascular lymphocytic infiltrates and rare focal myonecrosis were evident on biopsy at 2 weeks postoperatively, and mycophenolate mofetil was added. Subsequent VASM biopsies showed predominately interstitial and periva...Continue Reading

References

Feb 1, 1992·Transplantation·H W SollingerR S Kauffman
Mar 1, 1991·Plastic and Reconstructive Surgery·C M TanA J Weiland
Mar 1, 1991·Plastic and Reconstructive Surgery·W P LeeA J Weiland
Feb 1, 1991·Scandinavian Journal of Immunology·E M EuguiA C Allison
Dec 1, 1987·Plastic and Reconstructive Surgery·G B StarkJ W Futrell
Nov 1, 1986·Archives of Dermatology·A K GuptaH F Haberman
May 1, 1971·Plastic and Reconstructive Surgery·J E Murray

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Citations

Mar 9, 2002·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·M LanzettaM Dawahra
Aug 19, 2006·Anti-cancer Drugs·Claudia Lanvers-KaminskyJoachim Boos
Aug 19, 2007·Plastic and Reconstructive Surgery·Dalibor VasilicE Steve Woodle
Oct 1, 2011·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·J H BarkerJ M Frank
Apr 27, 2010·Expert Opinion on Biological Therapy·Simon M GrahamEleftherios Tsiridis
Apr 11, 2012·Journal of Neuropathology and Experimental Neurology·Daniel Skuk
Sep 3, 2008·The Journal of Hand Surgery·Warren C BreidenbachVijay S Gorantla
Oct 2, 2007·Annales de chirurgie plastique et esthétique·A GazarianA Eljaafari
Apr 28, 1999·Lancet·J M DubernardN S Hakim
Oct 11, 2020·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Calum HoneymanHenk Giele
Sep 20, 2002·The Journal of Hand Surgery·Neil F Jones
Jun 28, 2005·Clinics in Plastic Surgery·Claire L F Temple, Douglas C Ross

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