Transplantation tolerance induced by regulatory T cells: in vivo mechanisms and sites of action

International Immunopharmacology
Dela GolshayanManuel Pascual

Abstract

The mechanisms by which CD4(+)CD25(+)Foxp3(+) T (Treg) cells regulate effector T cells in a transplantation setting and their in vivo homeostasis still remain to be clarified. Using a mouse adoptive transfer model, we analyzed the in vivo expansion, trafficking, and effector function of alloreactive T cells and donor-specific Treg cells, in response to a full-thickness skin allograft. Fluorescent-labeled CD4(+)CD25(-) and antigen-specific Treg cells were transferred alone or co-injected into syngeneic BALB/c-Nude recipients transplanted with skins from (C57BL/6 x BALB/c) F1 donors. Treg cells divided in vivo, migrated and accumulated in the allograft draining lymph nodes as well as within the graft. The co-transfer of Treg cells did not modify the early activation and homing of CD4(+)CD25(-) T cells in secondary lymphoid organs. However, in the presence of Treg cells, alloreactive CD4(+)CD25(-) T cells produced significantly less IFN-gamma and were present in reduced numbers in the secondary lymphoid organs. Furthermore, time-course studies showed that Treg cells were recruited into the allograft at a very early stage after transplantation and effectively prevented the infiltration of effector T cells. In conclusion, suppressio...Continue Reading

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Citations

Jun 8, 2012·International Journal of Endocrinology·Sumantha BhattShiguang Qian
May 30, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·S LangierA Bonomo
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Mar 20, 2016·International Immunopharmacology·Xin ChenZhiMing Huang
Aug 24, 2010·Advances in Chronic Kidney Disease·James N Fleming, Nicole A Weimert
Aug 25, 2016·Transplantation Reviews·Reza ElahimehrDianne B McKay
Jul 14, 2016·Pathogens and Disease·Shivaprasad H VenkateshaKamal D Moudgil
Apr 13, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Behdad AfzaliGiovanna Lombardi
Dec 21, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefanie KoristkaMichael Bachmann

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