Transplanted Adipose-Derived Stem Cells Ameliorate Testicular Dysfunction In A D-Galactose-Induced Aging Rat Model

Journal of Cellular Physiology
Chun YangLin Yuan

Abstract

Glycation product accumulation during aging of slowly renewing tissues may be an important mechanism underlying aging of the testis. Adipose-derived stem cells (ADSCs) have shown promise in a novel tissue regenerative technique and may have utility in treating sexual dysfunction. ADSCs have also been found to be effective in antiaging therapy, although the mechanism underlying their effects remains unknown. This study was designed to investigate the anti-aging effect of ADSCs in a D-galactose (D-gal)-induced aging animal model and to clarify the underlying mechanism. Randomly selected 6-week-old male Sprague-Dawley rats were subcutaneously injected with D-gal daily for 8 weeks. Two weeks after completion of treatment, D-gal-induced aging rats were randomized to receive caudal vein injections of 3 × 10(6) 5-bromo 2'deoxy-uridine-labeled ADSCs or an equal volume of phosphate-buffered saline. Serum testosterone level, steroidogenic enzymes (3-β-hydroxysteroid dehydrogenase), and superoxide dismutase (SOD) activity decreased significantly in aging rats compared with the control group; serum lipid peroxidation, spermatogenic cell apoptosis, and methane dicarboxylic aldehyde (MDA) expression increased significantly. ADSCs increased t...Continue Reading

References

May 1, 1978·Analytical Biochemistry·M Mihara, M Uchiyama
Jul 16, 1999·Mechanisms of Ageing and Development·X SongY M Li
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·H Chen, B R Zirkin
Sep 20, 2000·Biology of Reproduction·B R Zirkin, H Chen
May 29, 2001·Current Medicinal Chemistry·S C Sikka
Dec 12, 2002·Molecular Biology of the Cell·Patricia A ZukMarc H Hedrick
Mar 26, 2003·Biogerontology·Shih-Ching HoReY-Yih Wu
Mar 18, 2004·The Journal of Steroid Biochemistry and Molecular Biology·Luchuan CaoSalman Azhar
Jan 11, 2005·Behavioural Brain Research·Haifeng WeiWei Li
Nov 24, 2005·Journal of Andrology·Lindi LuoBarry R Zirkin
Jan 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey L SpeesDarwin J Prockop
May 9, 2007·Reproductive Toxicology·Sivasankaran RajeswaryMaria Michael Aruldhas
Jun 24, 2008·Journal of Andrology·Terry T Turner, Jeffrey J Lysiak
Jun 25, 2008·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xiu-Li ZhangBo Jiang
Jul 12, 2008·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Byung-Soon ParkWon-Serk Kim
Jul 16, 2008·Biogerontology·Yang XuZhengwei Fu
Apr 28, 2009·Archives of Dermatological Research·Won-Serk KimJong-Hyuk Sung
May 9, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Audrey CarrièreLouis Casteilla
Jun 16, 2009·Expert Opinion on Biological Therapy·Won-Serk KimJong-Hyuk Sung
Jun 30, 2009·Toxicon : Official Journal of the International Society on Toxinology·Qian XiongYing Liu
Jul 9, 2009·Bioscience, Biotechnology, and Biochemistry·Anjun LiuZhenyuan Zhu
Sep 23, 2010·BMC Complementary and Alternative Medicine·Wan-Loy ChuPhaik-Eem Lim
Sep 30, 2010·European Journal of Clinical Investigation·Rosalinda MadonnaRaffaele De Caterina
Jul 2, 2011·Ecotoxicology and Environmental Safety·Kalist Shagirtha, Leelavinothan Pari
Sep 21, 2013·Urologia Internationalis·Semra YigitaslanAli Barbaros Baseskioglu
Feb 7, 2014·Systems Biology in Reproductive Medicine·Michael Clarke, Christopher A Pearl
Mar 7, 2014·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sherine M RizkMary A M Mina

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Citations

Jun 14, 2016·European Journal of Pharmacology·Františka HorváthováJozef Mihalik
Nov 9, 2016·World Journal of Stem Cells·Taylor C PeakWayne J Hellstrom
Oct 1, 2019·Molecular Reproduction and Development·Malsawmhriatzuala JeremyVikas Kumar Roy
Jul 1, 2021·Nature Reviews. Urology·Lu Li, Vassilios Papadopoulos

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