Transplanted mesenchymal stem cells with pure fibrinous gelatin-transforming growth factor-beta1 decrease rabbit intervertebral disc degeneration

The Spine Journal : Official Journal of the North American Spine Society
Huilin YangNabil A Ebraheim

Abstract

Disc degeneration is a major reason for low back pain and can be caused by apoptosis. The prevention of apoptosis using mesenchymal stem cells (MSCs) may lead to new treatments for low back pain. Previous studies have reported that transplanted MSCs can proliferate and differentiate into cells expressing some of the major phenotypic qualities of nucleus pulposus cells. However, the effects of MSC transplantation on the disc height index (DHI) and apoptosis inhibition have not yet been thoroughly investigated. The present study evaluates the effects of MSC transplantation on DHI and its potential to inhibit apoptosis. Random, controlled, animal experiment study. The annulus fibrosus of 54 white New Zealand rabbits was punctured with a 21-gauge needle, and the nucleus pulposus tissue from the intervertebral discs was aspirated. The degenerative disc model was produced in each rabbit, which were then randomly divided into three groups: degenerative model group; pure fibrinous gelatin-transforming growth factor-beta1 (PFG-TGF-beta1) transplanted group; and MSC-PFG-TGF-beta1 transplanted group. Computed radiography imaging, magnetic resonance imaging, and histological examinations were performed at Weeks 4, 8, and 12. The transplant...Continue Reading

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References

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Citations

Mar 26, 2014·The Spine Journal : Official Journal of the North American Spine Society·Li NiHuilin Yang
May 3, 2014·Tissue Engineering. Part a·Fackson MwaleLisbet Haglund
Mar 21, 2013·Apoptosis : an International Journal on Programmed Cell Death·Fan DingLi-ming Xiong
Apr 18, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Bin HeFeng Li
Mar 10, 2015·Neurosurgical Review·David OehmeGraham Jenkin
Feb 25, 2015·Nature Reviews. Rheumatology·Daisuke Sakai, Gunnar B J Andersson
Feb 2, 2013·The Spine Journal : Official Journal of the North American Spine Society·Isaac L MossHoward S An
Dec 18, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Wei TongYejia Zhang
Sep 3, 2013·Cell Transplantation·Lin ChenPaul R Sanberg
May 21, 2018·Biomolecular Concepts·Justin C KennonSadanand Fulzele
Jun 2, 2016·World Journal of Stem Cells·Gianluca VadalàVincenzo Denaro
Jan 23, 2016·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Jee Won ChaiSung Hwan Hong
Jul 28, 2011·Transplantation·Lluis OrozcoJavier García-Sancho
Sep 7, 2019·Current Stem Cell Research & Therapy·Ying Chen, Liling Tang
Sep 17, 2017·Oncotarget·Zhi-Hua OuyangGuo-Hua Lv
Jun 13, 2020·Global Spine Journal·Derek G JuHyun W Bae
Aug 25, 2018·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·G W OmlorW Richter

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