Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury

The Journal of Immunology : Official Journal of the American Association of Immunologists
Lidia BosurgiPatrizia Rovere-Querini

Abstract

The aim of this study was to verify whether macrophages influence the fate of transplanted mesoangioblasts--vessel-associated myogenic precursors--in a model of sterile toxin-induced skeletal muscle injury. We have observed that in the absence of macrophages, transplanted mesoangioblasts do not yield novel fibers. Macrophages retrieved from skeletal muscles at various times after injury display features that resemble those of immunoregulatory macrophages. Indeed, they secrete IL-10 and express CD206 and CD163 membrane receptors and high amounts of arginase I. We have reconstituted the muscle-associated macrophage population by injecting polarized macrophages before mesoangioblast injection: alternatively activated, immunoregulatory macrophages only support mesoangioblast survival and function. This action depends on the secretion of IL-10 in the tissue. Our results reveal an unanticipated role for tissue macrophages in mesoangioblast function. Consequently, the treatment of muscle disorders with mesoangioblasts should take into consideration coexisting inflammatory pathways, whose activation may prove crucial for its success.

References

Jan 1, 1995·Journal of Neuropathology and Experimental Neurology·M Cantini, U Carraro
Aug 15, 1994·Biochemical and Biophysical Research Communications·M CantiniU Carraro
Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Aug 1, 1993·Experimental Cell Research·T A RobertsonJ M Papadimitriou
Jun 27, 1997·Biochemical and Biophysical Research Communications·M L MassiminoU Carraro
Mar 13, 2001·Annual Review of Immunology·K W MooreA O'Garra
May 8, 2002·The Journal of Cell Biology·Tetsuro TamakiV Reggie Edgerton
May 22, 2002·The Journal of Cell Biology·Zhuqing Qu-PetersenJohnny Huard
Oct 16, 2002·The Journal of Cell Biology·Atsushi AsakuraMichael A Rudnicki
Jan 1, 2003·Rheumatic Diseases Clinics of North America·Marinos C Dalakas
Jan 30, 2003·Journal of Leukocyte Biology·David M Mosser
Mar 12, 2003·The Journal of Cell Biology·Cosimo De BariFrank P Luyten
Oct 11, 2003·Current Opinion in Genetics & Development·Giulio Cossu, Paolo Bianco
Dec 10, 2003·The Journal of Cell Biology·Bénédicte ChazaudRomain K Gherardi
Mar 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Estanislao BachrachLouis M Kunkel
Dec 17, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gordon L WarrenPetia P Simeonova
Jan 8, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·James G Tidball
Aug 13, 2005·Seminars in Cell & Developmental Biology·Chet E Holterman, Michael A Rudnicki
Jan 21, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mukesh SummanPetia P Simeonova
May 25, 2006·Journal of Cell Science·Corinne SonnetBénédicte Chazaud
Aug 26, 2006·Current Opinion in Genetics & Development·Margaret Buckingham
Nov 17, 2006·Nature·Maurilio SampaolesiGiulio Cossu
Dec 1, 2006·Journal of Leukocyte Biology·Paula K ShiremanLinda M McManus
Dec 5, 2006·Stem Cell Reviews·Richard O C OreffoMark Clements
Feb 1, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Laura PelosiAntonio Musarò
Feb 13, 2007·Nature Cell Biology·Arianna DellavalleGiulio Cossu
Mar 28, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Bruno PéaultJohnny Huard
May 9, 2007·The Journal of Experimental Medicine·Ludovic ArnoldBénédicte Chazaud
Nov 13, 2007·Current Opinion in Cell Biology·Fabien Le Grand, Michael A Rudnicki
Feb 14, 2008·American Journal of Physiology. Endocrinology and Metabolism·Klemen StrleKeith W Kelley
Mar 29, 2008·Cell Stem Cell·Zuzana Tothova, D Gary Gilliland
Mar 29, 2008·Cell Stem Cell·Shihuan KuangMichael A Rudnicki
Jul 22, 2008·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Silvia Brunelli, Patrizia Rovere-Querini

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Citations

Mar 20, 2013·Mediators of Inflammation·Yacine KharrazPura Muñoz-Cánoves
Apr 30, 2014·BioMed Research International·Laura Cristina CeafalanMihail Eugen Hinescu
Oct 29, 2015·Mediators of Inflammation·Domiziana CostamagnaFabio Penna
May 27, 2014·BioMed Research International·Elena RigamontiSilvia Brunelli
Feb 13, 2016·Cell Death and Differentiation·C ScioratiP Rovere-Querini
Aug 3, 2018·Antioxidants & Redox Signaling·Francesca De SantaElisabetta Ferraro
Apr 10, 2015·Cellular and Molecular Life Sciences : CMLS·Clara ScioratiPatrizia Rovere-Querini
Apr 24, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Darcée D SlobodaSusan V Brooks
Apr 23, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lara CampanaPatrizia Rovere-Querini
Jul 29, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gianfranca CornaPatrizia Rovere-Querini
Aug 31, 2018·International Immunology·Yumiko Oishi, Ichiro Manabe
Jan 28, 2016·Arthritis & Rheumatology·Yoko Yoshihashi-NakazatoHitoshi Kohsaka
Apr 23, 2014·Clinical and Experimental Immunology·L BosurgiP Rovere-Querini
Mar 9, 2018·Frontiers in Immunology·Angelo A ManfrediNorma Maugeri
Mar 6, 2019·Frontiers in Physiology·Fabio PennaPaola Costelli
Mar 23, 2019·Stem Cell Research & Therapy·Shuzhi Teng, Ping Huang
Mar 7, 2014·Development·James G TidballMichelle Wehling-Henricks
Jun 3, 2021·Biomolecules·Emilia ManoleMihail Eugen Hinescu
Jun 14, 2021·Cell Death & Disease·Nour Al-ZaeedZsolt Sarang

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