Transplanting neural progenitor cells to restore connectivity after spinal cord injury.

Nature Reviews. Neuroscience
Itzhak FischerMichael A Lane

Abstract

Spinal cord injury remains a scientific and therapeutic challenge with great cost to individuals and society. The goal of research in this field is to find a means of restoring lost function. Recently we have seen considerable progress in understanding the injury process and the capacity of CNS neurons to regenerate, as well as innovations in stem cell biology. This presents an opportunity to develop effective transplantation strategies to provide new neural cells to promote the formation of new neuronal networks and functional connectivity. Past and ongoing clinical studies have demonstrated the safety of cell therapy, and preclinical research has used models of spinal cord injury to better elucidate the underlying mechanisms through which donor cells interact with the host and thus increase long-term efficacy. While a variety of cell therapies have been explored, we focus here on the use of neural progenitor cells obtained or derived from different sources to promote connectivity in sensory, motor and autonomic systems.

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Citations

Jan 6, 2021·International Journal of Molecular Sciences·Esther GiraldoVictoria Moreno-Manzano
Feb 10, 2021·Cell Transplantation·Liyi HuangQuan Wei
Jan 29, 2021·Frontiers in Cellular Neuroscience·Anne Huntemer-SilveiraAnn M Parr
Feb 16, 2021·Frontiers in Cellular Neuroscience·Jakub ČervenkaPetr Vodička
Apr 9, 2021·Expert Opinion on Biological Therapy·William Brett McIntyreMichael G Fehlings
Jun 3, 2021·International Journal of Molecular Sciences·Pablo BonillaVictoria Moreno-Manzano
Jul 25, 2021·Cell and Tissue Research·Yu-Hsuan ChuChristian Schachtrup
Aug 20, 2021·Frontiers in Cellular Neuroscience·Dylan A McCreedyTodd C McDevitt
Sep 30, 2021·Science Advances·Christopher RathnamKi-Bum Lee
Oct 23, 2021·Experimental and Therapeutic Medicine·Jian-Tao LiuHua-Nan Li
Nov 26, 2021·Cell and Tissue Research·Alexandra M NicaiseStefano Pluchino
Dec 2, 2021·ACS Biomaterials Science & Engineering·John D KruttyPadma Gopalan
Jan 28, 2022·Experimental Neurology·Tara A FortinoMichael A Lane

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Methods Mentioned

BETA
transgenic
biopsy
electron microscopy
imaging techniques
xenograft

Software Mentioned

Neuralstem
NeuroRegen

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