Transplanting the pulmonary virome: Dynamics of transient populations

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
Alicia B MitchellAllan R Glanville

Abstract

Lung transplantation provides a unique opportunity to investigate the dynamics of the human pulmonary virome that is transplanted within the donor lungs. The pulmonary virome comprises both "resident" and "transient" viruses. In this study we aimed to analyze the dynamics of the "transient" members. We conducted a single-center, prospective, longitudinal investigation of community-acquired respiratory viruses detected in nasopharyngeal swabs, swabs of explanted and donor lungs, and serial bronchoalveolar lavages post-transplant. Fifty-two consecutive lung transplant recipients were recruited (bilateral:heart‒lung:bilateral lung-liver = 48:2:2) (age [mean ± SD] 48 ± 15 years, range 20 to 63 years; 27 males and 25 females). Follow-up was 344 ± 120 (range 186 to 534) days. Seventeen of 45 explanted lungs were positive for influenza A and/or B (A = 14, B = 2, A+B = 1), despite recipient vaccination and negative nasal swabs, and 4 of 45 had human rhinovirus and 2 of 45 parainfluenza. Donor swabs showed influenza (A = 1, B = 1) and rhinovirus (n = 3). Day 1 lavage showed influenza A (n = 28), rhinovirus (n = 9), and parainfluenza (n = 1). Forty-seven of 52 recipients had a positive lavage for virus (38 of 47 on multiple lavages). Inf...Continue Reading

Citations

May 26, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Auke E S de ZwartErik A M Verschuuren
May 16, 2019·Current Opinion in Organ Transplantation·Alicia B Mitchell
Mar 23, 2021·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Caroline C EskindGowri Satyanarayana
Jun 15, 2021·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·John E McGinnissRonald G Collman
Jun 14, 2019·Current Opinion in Organ Transplantation·Fernando Dominguez, Emily Blodget

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