Transpleural gradient of 1,25-dihydroxyvitamin D in tuberculous pleuritis

The Journal of Clinical Investigation
P F BarnesJ S Adams

Abstract

We used tuberculous pleuritis as a model to study the compartmentalization and potential immunoregulatory role of 1,25-dihydroxyvitamin D [1,25-(OH)2-D] in human granulomatous disease. In tuberculous pleuritis, mean concentrations of total 1,25-(OH)2-D were elevated in pleural fluid, compared to blood (67 pg/ml vs. 35 pg/ml). Concentrations of albumin, protein and 25-hydroxyvitamin D (25-OH-D) were lower in pleural fluid than blood, suggesting that accumulation of binding proteins does not explain the transpleural gradient of 1,25-(OH)2-D. The mean free 1,25-(OH)2-D concentration in pleural fluid was increased 5.3-fold over that in serum. 1,25-(OH)2-D3 inhibited PPD-induced proliferation of pleural fluid mononuclear cells, antigen-reactive lines and T lymphocyte clones derived from a single cell. Patient-derived PPD-reactive lines expressed a high-affinity intracellular binding moiety for 1,25-(OH)2-D3. Pleural fluid mononuclear cells and PPD-reactive lines did not metabolize 25-OH-D3 to 1,25-(OH)2-D3. The sum of these data suggests that concentration of 1,25-(OH)2-D in pleural fluid of tuberculosis patients is probably due to local hormone production by pleural tissue-based inflammatory cells that are not present in significan...Continue Reading

References

Jan 1, 1988·The Journal of Clinical Endocrinology and Metabolism·J S Adams, M A Gacad
Sep 1, 1987·The Journal of Clinical Endocrinology and Metabolism·H ReichelA W Norman
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·J S AdamsM F Holick
Feb 1, 1988·Immunology Today·W F Rigby
Dec 1, 1986·Annals of Internal Medicine·V N Hoffman, O M Korzeniowski
Nov 1, 1985·The Journal of Clinical Endocrinology and Metabolism·D D BikleJ G Haddad
Jul 31, 1974·Clinica Chimica Acta; International Journal of Clinical Chemistry·M A PreeceE Kodicek
Jan 1, 1973·Chest·H W Berger, E Mejia
Nov 13, 1981·Journal of Chromatography·J S AdamsM F Holick
Sep 16, 1983·Science·D M ProvvediniS C Manolagas
Oct 1, 1984·The Journal of Clinical Investigation·W F RigbyM W Fanger
Oct 25, 1984·The New England Journal of Medicine·G A KozenyJ E Hano
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E AbeT Suda
Jan 1, 1984·The Journal of Clinical Endocrinology and Metabolism·T A ReinhardtB W Hollis

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Citations

Feb 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J M Lemire, J S Adams
Mar 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S ShanyJ S Adams
May 1, 1992·Journal of Cellular Biochemistry·J M Lemire
Aug 25, 2000·Current Opinion in Pulmonary Medicine·O P Sharma
Nov 29, 2013·Science Translational Medicine·Robert L Modlin, Barry R Bloom
Mar 26, 2003·Annual Review of Nutrition·Matthew D GriffinRajiv Kumar
Oct 25, 2002·American Journal of Respiratory Cell and Molecular Biology·Mercedes AlemánMaría C Sasiain
Feb 10, 2007·The Journal of Clinical Investigation·Jürgen SchauberRichard L Gallo
Feb 5, 2009·Pediatric Research·Valencia P Walker, Robert L Modlin
May 19, 2012·Endocrine Reviews·Clifford J RosenChristopher S Kovacs
May 22, 2013·Mediators of Inflammation·Sabino ScollettaClara Crescioli
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John S AdamsMartin Hewison
Jan 7, 2014·The Journal of Steroid Biochemistry and Molecular Biology·John S AdamsPhilip T Liu
Aug 10, 2016·The Clinical Respiratory Journal·Marios PanagiotouNapoleon Karagianidis
Dec 22, 2006·Respiratory Medicine·Marios E FroudarakisPhilippe Astoul
Jul 11, 2009·American Journal of Respiratory and Critical Care Medicine·Claudia JafariUNKNOWN Tuberculosis Network European Trialsgroup
Sep 3, 2016·Endocrine Reviews·Peter J TebbenRajiv Kumar
Apr 30, 2004·Clinica Chimica Acta; International Journal of Clinical Chemistry·L J Burgess
Jun 1, 1997·Current Problems in Surgery·F K ChanJ P Bilezikian

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