PMID: 696345Aug 1, 1978Paper

Transport and binding of lidocaine by lung slices and perfused lung of rats

Acta Pharmacologica Et Toxicologica
C PostE Nilsson

Abstract

The accumulation of radioisotopically labelled lidocaine was investigated in lung slices and perfused lungs of rats. Lidocaine was taken up by rat lung slices incubated in an oxygenated physiological solution (pH 7.4) at 37 degrees. 14C-lidocaine accumulated in lung slices to a much greater extent than did 3H-sucrose, and the lidocaine space was approximately 7 times that of the extracellular space. No metabolism of lidocaine took place during the incubation period. The accumulation of lidocaine was inhibited by low temperature, while anaerobic conditions had no inhibitor effect. The uptake of lidocaine (0.028 mM) was slightly antagonized by high concentrations of Ca2+ (10 mM). The isolated perfused lung model was used for studying the pulmonary absorption of lidocaine from the vascular bed. Lidocaine was rapidly extracted from the perfusion solution and the drug appeared to accumulate in at least two compartments. It seems that in the rat lung a portion of the lidocaine taken up had accumulated within the cells, while some of it may be fixed to the cell surfaces.

References

Jul 1, 1974·Clinical Pharmacology and Therapeutics·N BenowitzM Rowland
Jan 1, 1965·Acta Pharmacologica Et Toxicologica·E HANSSONL KRISTERSON

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Citations

Jan 1, 1983·Drug Metabolism Reviews·H Kurz, B Fichtl
Sep 1, 1981·Acta Pharmacologica Et Toxicologica·A R Hede, C Post
Aug 1, 1982·Acta Pharmacologica Et Toxicologica·C Post, K Eriksdotter-Behm
Apr 1, 1996·Acta Anaesthesiologica Scandinavica·K HasegawaM Fujimori
Feb 26, 1998·Journal of Applied Physiology·S H AudiD L Roerig
Nov 1, 1979·Acta Pharmacologica Et Toxicologica·C Post, R G Andersson
Mar 1, 1991·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·F A BurrowsH A Strong
Feb 1, 1979·Acta Pharmacologica Et Toxicologica·C PostE Nilsson
Jan 9, 2013·Expert Opinion on Drug Metabolism & Toxicology·Xin LiuMichael S Roberts
Dec 1, 1979·Acta Anaesthesiologica Scandinavica·L JorfeldtC Post
Jul 1, 1979·British Journal of Pharmacology·B E Hall, S P James
Aug 1, 1991·Pharmacology & Toxicology·M G PalazzoJ Sear
May 16, 2009·European Journal of Anaesthesiology·Michael FlondorChristian Hofstetter
Jan 1, 1981·European Journal of Drug Metabolism and Pharmacokinetics·R F MinchinB W Madsen
Jan 1, 1986·Lung·J A PangD M Geddes
Mar 15, 1994·Biochemical Pharmacology·K TanakaY Funae
Jan 1, 1989·Pharmacology & Therapeutics·U S Ryan, C J Grantham
Mar 1, 1984·Journal of Pharmaceutical Sciences·N Khalafallah, W J Jusko

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