Transport and cellular uptake of polychlorinated biphenyls (PCBs)--I. Association of individual PCB isomers and congeners with plasma lipoproteins and proteins in the pigeon

Biochemical Pharmacology
J T BorlakogluR R Dils

Abstract

Polychlorinated biphenyls (PCBs) are abundant and persistent pollutants in the ecosystem. Commercial mixtures (e.g. Aroclor 1254) can contain up to 80 different isomers and congeners, many of which accumulate in biological systems by the ingestion of PCB-contaminated lipid components of food chains. PCBs are lipophilic and lipid-rich lipoproteins provide an excellent system to transport PCBs to tissues. We report here the distribution of PCBs between plasma fractions in the pigeon. Twenty-four hours after injection, [14C]4-monochlorobiphenyl and [14C]2,2',5,5'-tetrachlorobiphenyl were associated with the protein-rich HDL fraction and the lipoprotein-poor fraction (predominantly albumin), rather than with the lipid-rich VLDL and LDL fractions. Five days after injection with the commercial PCB mixture Aroclor 1254, there was a distinctive distribution between the plasma fractions of the 41 congeners detected. Avian species have a poorly developed lymphatic system and dietary lipids are secreted into the portal vein. To emphasize this route of entry, the lipoprotein particles formed are termed portomicrons rather than chylomicrons. The most striking result was that the lipid-rich portomicron and the VLDL fraction was associated al...Continue Reading

References

Jan 1, 1976·Current Topics in Cellular Regulation·J L Goldstein, M S Brown
Nov 1, 1977·Metabolism: Clinical and Experimental·J L Goldstein, M S Brown
Apr 1, 1989·European Journal of Drug Metabolism and Pharmacokinetics·J T Borlakoglu, C H Walker
Jan 1, 1987·Annual Review of Pharmacology and Toxicology·R D Kimbrough
Dec 1, 1986·Environmental Health Perspectives·P A Stehr-GreenK Steinberg
Mar 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L A Gallenberg, M J Vodicnik
May 1, 1987·Archives of Environmental Contamination and Toxicology·Y TakagiN Ikegami
Jan 1, 1987·Annual Review of Biochemistry·D W Nebert, F J Gonzalez
Sep 30, 1983·Toxicology and Applied Pharmacology·M S VomachkaJ J Lech
Jan 1, 1984·Annual Review of Pharmacology and Toxicology·H B Matthews, R L Dedrick

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Citations

Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J T BorlakogluR R Dils
Jul 31, 2013·Bulletin of Environmental Contamination and Toxicology·Jennifer M DaleyKen G Drouillard
Aug 14, 2020·Ecotoxicology and Environmental Safety·Dehou HaoLin Niu
Oct 23, 2008·Environmental Science & Technology·Matthew S RossCharles S Wong
Sep 3, 2008·Environmental Research·Philip Sebastian HjelmborgEva Cecilie Bonefeld-Jørgensen
Dec 15, 2010·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Kiyoshi Yamauchi, Gobun Sai

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