Abstract
The complex distribution of polychlorinated biphenyl (PCB) isomers and congeners amongst plasma fractions of the pigeon suggests that the lipid and apolipoprotein components of lipoproteins, as well as plasma proteins, may be important in transporting PCBs to tissues (Borlakoglu et al., Biochem. Pharmac. 40, 265 (1990]. Pigeons were injected with the commercial PCB mixture Aroclor 1254 (1.5 mmol/kg body weight). After 120 hr triacylglycerol-like droplets accumulated in hepatocytes ('fatty liver syndrome'), there was proliferation of the hepatic smooth endoplasmic reticulum, and plasma concentrations of triacylglycerol and total cholesterol increased. This was accompanied by significant decreases in plasma concentrations of total protein, total apolipoproteins of the low density lipoprotein (LDL) and the high density lipoprotein (HDL) fractions, and albumin and by a significant increase in that of urea, indicating increased protein breakdown. These results suggest that Aroclor 1254 increased hepatic lipid synthesis, but decreased hepatic production of albumin and apolipoproteins. This would explain the accumulation of triacylglycerol in the liver and the increase in the proportion of triacylglycerol to apolipoprotein in the tota...Continue Reading
References
May 1, 1979·Chemico-biological Interactions·K K KohliJ D McKinney
Jan 1, 1976·Current Topics in Cellular Regulation·J L Goldstein, M S Brown
Nov 1, 1977·Metabolism: Clinical and Experimental·J L Goldstein, M S Brown
Jan 29, 1990·Biochimica Et Biophysica Acta·A NelsonJ Borlakoglu
Mar 10, 1990·European Journal of Biochemistry·J T BorlakogluR R Dils
Jul 15, 1990·Biochemical Pharmacology·J T BorlakogluR R Dils
Sep 1, 1989·Biochemical Pharmacology·S SouèsP Lesca
Jan 1, 1987·Annual Review of Pharmacology and Toxicology·R D Kimbrough
Dec 1, 1986·Environmental Health Perspectives·P A Stehr-GreenK Steinberg
Mar 1, 1987·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·L A Gallenberg, M J Vodicnik
May 1, 1987·Archives of Environmental Contamination and Toxicology·Y TakagiN Ikegami
Jan 1, 1987·Annual Review of Biochemistry·D W Nebert, F J Gonzalez
May 1, 1985·Proceedings of the Society for Experimental Biology and Medicine·D L BusbeeC O Joe
Nov 1, 1972·Archives of Environmental Health·R D KimbroughT B Gaines
Jan 1, 1984·Critical Reviews in Toxicology·S Safe
Sep 1, 1983·Archives of Environmental Contamination and Toxicology·M BaumannH Greim
Jan 1, 1983·Residue Reviews·M R Bleavins, R J Aulerich
Feb 1, 1980·Experimental and Molecular Pathology·P O Sandberg, H Glaumann
Oct 1, 1980·American Journal of Epidemiology·E L BakerL L Needham
Feb 1, 1982·Environmental Research·D Kling, W Gamble
May 1, 1982·The Journal of Nutrition·N KatoA Yoshida
Jan 1, 1981·Archives of Environmental Contamination and Toxicology·H T JonssonG R Hennigar
Apr 1, 1972·Environmental Health Perspectives·D B PeakallS E Bloom
Citations
May 14, 2008·Ecotoxicology·Mihoko NumataRhonda J Rosengren
May 7, 2013·Environmental Science and Pollution Research International·Hua ShenGabriele Ludewig
Nov 9, 2001·Journal of Toxicology and Environmental Health. Part a·R KäkeläJ Asikainen
Apr 28, 1997·Toxicology Letters·K MatsusueK Oguri
Nov 17, 2015·Pediatric Research·Pankaj K SethiJames V Bruckner
Nov 19, 1997·Placenta·C J JonesV Dantzer
Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J T BorlakogluR R Dils
Apr 24, 2014·Journal of Toxicology and Environmental Health. Part a·Nina Hårdnes TremoenAnette Krogenæs
Dec 4, 2014·PloS One·Nishika SahiniJürgen Borlak
Sep 24, 2005·Cell Biochemistry and Function·Selim KutluBayram Yilmaz
Sep 12, 1991·Biochemical Pharmacology·H GriffinJ Brolakoglu
Apr 18, 1994·Toxicology·F P BellT J Vidmar
Sep 3, 2008·Environmental Research·Philip Sebastian HjelmborgEva Cecilie Bonefeld-Jørgensen