Transport and cellular uptake of polychlorinated biphenyls (PCBs)--II. Changes in vivo in plasma lipoproteins and proteins of pigeons in response to PCBs, and a proposed model for the transport and cellular uptake of PCBs

Biochemical Pharmacology
J T BorlakogluR R Dils

Abstract

The complex distribution of polychlorinated biphenyl (PCB) isomers and congeners amongst plasma fractions of the pigeon suggests that the lipid and apolipoprotein components of lipoproteins, as well as plasma proteins, may be important in transporting PCBs to tissues (Borlakoglu et al., Biochem. Pharmac. 40, 265 (1990]. Pigeons were injected with the commercial PCB mixture Aroclor 1254 (1.5 mmol/kg body weight). After 120 hr triacylglycerol-like droplets accumulated in hepatocytes ('fatty liver syndrome'), there was proliferation of the hepatic smooth endoplasmic reticulum, and plasma concentrations of triacylglycerol and total cholesterol increased. This was accompanied by significant decreases in plasma concentrations of total protein, total apolipoproteins of the low density lipoprotein (LDL) and the high density lipoprotein (HDL) fractions, and albumin and by a significant increase in that of urea, indicating increased protein breakdown. These results suggest that Aroclor 1254 increased hepatic lipid synthesis, but decreased hepatic production of albumin and apolipoproteins. This would explain the accumulation of triacylglycerol in the liver and the increase in the proportion of triacylglycerol to apolipoprotein in the tota...Continue Reading

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Citations

May 7, 2013·Environmental Science and Pollution Research International·Hua ShenGabriele Ludewig
Nov 9, 2001·Journal of Toxicology and Environmental Health. Part a·R KäkeläJ Asikainen
Nov 17, 2015·Pediatric Research·Pankaj K SethiJames V Bruckner
Apr 1, 1991·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·J T BorlakogluR R Dils
Sep 24, 2005·Cell Biochemistry and Function·Selim KutluBayram Yilmaz
Sep 3, 2008·Environmental Research·Philip Sebastian HjelmborgEva Cecilie Bonefeld-Jørgensen

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