Transport and cytotoxicity of the anticancer drug 3-bromopyruvate in the yeast Saccharomyces cerevisiae.

Journal of Bioenergetics and Biomembranes
Paweł LisStanisław Ułaszewski

Abstract

We have investigated the cytotoxicity in Saccharomyces cerevisiae of the novel antitumor agent 3-bromopyruvate (3-BP). 3-BP enters the yeast cells through the lactate/pyruvate H(+) symporter Jen1p and inhibits cell growth at minimal inhibitory concentration of 1.8 mM when grown on non-glucose conditions. It is not submitted to the efflux pumps conferring Pleiotropic Drug Resistance in yeast. Yeast growth is more sensitive to 3-BP than Gleevec (Imatinib methanesulfonate) which in contrast to 3-BP is submitted to the PDR network of efflux pumps. The sensitivity of yeast to 3-BP is increased considerably by mutations or chemical treatment by buthionine sulfoximine that decrease the intracellular concentration of glutathione.

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Citations

Feb 29, 2016·Pharmacological Reports : PR·Izabela Sadowska-BartoszGrzegorz Bartosz
Apr 10, 2014·Cellular & Molecular Biology Letters·Izabela Sadowska-BartoszGrzegorz Bartosz
Oct 2, 2013·Bioscience Reports·Nívea Dias AmoêdoFranklin David Rumjanek
Apr 2, 2013·Biochemical and Biophysical Research Communications·Mariusz DylągStanisław Ułaszewski
Nov 5, 2016·Biochimica Et Biophysica Acta·Xianbin SuJimmy S H Tsang
Dec 17, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Paweł LisStanisław Ułaszewski
Jun 17, 2015·Antimicrobial Agents and Chemotherapy·Loyze Paola O de LimaHelene S Barbosa
May 5, 2018·Frontiers in Pharmacology·Tomasz JagielskiMariusz Dyląg
Apr 18, 2019·FEMS Yeast Research·Katarzyna NiedźwieckaStanisław Ułaszewski
Jul 3, 2021·International Journal of Molecular Sciences·Magdalena CalStanisław Ułaszewski

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