PMID: 1123757Jan 1, 1975

Transport and electrical phenomena in resting and secreting piglet gastric mucosa

The Journal of Physiology
J G Forte, T E Machen

Abstract

1. Gastric mucosae were isolated from piglets (0-5 days old) and mounted in a chamber where electrical properties and secretory function could be measured. Unlike many previously reported mammalian in vitro preparations, pig gastric mucosae were stable and physiologically responsive for many hours after isolation. 2. With similar Ringer solutions bathing both surfaces, the isolated piglet gastric mucosa maintained a p.d. with the mucosal surface 30-35 mV negative with respect to the serosal surface. Limitation of access of Na+ from the mucosal bathing solution to the tissue (e.g. replacement of Na+ on mucosal side with choline or treatment with 10- minus 5 M amiloride) produced a decrease in p.d. and increase in mucosal resistance consistent with an hypothesis of Na+ transport from mucosa to serosa. 3. Isotopic flux measurements (36Cl and 24Na) and net H+ secretory rate were performed during open and short-circuit conditions, while the tissue was at rest and after stimulation of HCl secretion by 6 times 10- minus 5 M histamine. Up to 90% of the respective short-circuit current for resting or secreting mucosae was accounted for as the algebraic sum of Cl minus, H+ or Na+ fluxes. 4. The net transport of Na+ which occurred from mu...Continue Reading

Citations

Jun 1, 1983·Journal of Bioenergetics and Biomembranes·G KlempererS R Caplan
Jun 6, 2009·The Journal of Physiology·Penghong SongUrsula Seidler
Nov 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jie XuManoocher Soleimani
Jan 1, 1982·The Journal of Membrane Biology·G SachsE Rabon
Jun 1, 1984·Pflügers Archiv : European journal of physiology·Silvana Curci, T Schettino
Aug 12, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Nichole McDanielChristian Lytle
Feb 6, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·James M CrothersT E Machen
Dec 1, 1982·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T E Machen, T Zeuthen
Jan 1, 1990·Journal of Internal Medicine. Supplement·W S RehmM Schwartz
Oct 19, 2020·Cellular and Molecular Gastroenterology and Hepatology·Tyler J CaronSusan J Hagen

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Anaerobiosis
Chloride Ion Level
Electrophysiology (Science)
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