Transport efficiency in transdermal drug delivery: What is the role of fluid microstructure?

Colloids and Surfaces. B, Biointerfaces
Roberta LiuzziSergio Caserta

Abstract

Interaction of microstructured fluids with skin is ubiquitous in everyday life, from the use of cosmetics, lotions, and drugs, to personal care with detergents or soaps. The formulation of microstructured fluids is crucial for the control of the transdermal transport. In biomedical applications transdermal delivery is an efficient approach, alternative to traditional routes like oral and parenteral administration, for local release of drugs. Poor skin permeability, mainly due to its outer layer, which acts as the first barrier against the entry of external compounds, greatly limits the applicability of transdermal delivery. In this review, we focus on recent studies on the improvement of skin transport efficiency by using microemulsions (ME). Quantitative techniques, which are able to investigate both skin morphology and penetration processes, are also reviewed. ME are increasingly used as transdermal systems due to their low preparation cost, stability and high bioavailability. ME may act as penetration enhancers for many active principles, but ME microstructure should be chosen appropriately considering several factors such as ratio and type of ingredients and physic-chemical properties of the active components. ME microstruc...Continue Reading

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Citations

Sep 4, 2018·Expert Opinion on Therapeutic Patents·Marluce Pereira Damasceno LimaFernanda Regina de Castro Almeida
Nov 4, 2017·Drug Development and Industrial Pharmacy·Rita LangascoElisabetta Gavini
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Sep 27, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Mina SakuragiKatsuki Kusakabe

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