Apr 28, 2020

Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease

BioRxiv : the Preprint Server for Biology
Benoit DuchetR. Bogacz

Abstract

Parkinson's disease motor symptoms are associated with an increase in subthalamic nucleus beta band oscillatory power. But these oscillations are phasic, and there is a growing body of evidence suggesting that beta burst duration may be of critical importance to motor symptoms, making insights into the dynamics of beta bursting generation valuable. In this study, we ask the question ''Can average burst duration reveal how dynamics change between the ON and OFF medication states?''. Our analysis of local field potentials from the subthalamic nucleus demonstrates using linear surrogates that the system generating beta oscillations acts in a more non-linear regime OFF medication and that the change in the degree of non-linearity is correlated with motor impairment. Further, we pinpoint specific dynamical changes responsible for changes in the temporal patterning of beta oscillations between medication states by fitting to data biologically inspired models, and simpler beta envelope models. Finally, we show that the non-linearity can be directly extracted from average burst duration profiles under the assumption of constant noise in envelope models. This reveals that average burst duration profiles provide a window into burst dynam...Continue Reading

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Mentioned in this Paper

Axonal Transport
Tissue Membrane
Gait, Drop Foot
Membrane
Cell Motility
Kinesin Activity
Motility
Kinesin
Vesicle
Microtubules

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