PMID: 287Jan 1, 1975

Transport of 4-deoxy- and 6-deoxy-D-glucose in baker's yeast

Folia Microbiologica
A KotykV Soukupová

Abstract

Tritium-labelled 4-deoxy-D-glucose (4-dglc) and 6-deoxy-D-glucose (6-dgcl) were prepared by catalytic hydrogenolysis of the corresponding deoxyiodo derivatives with gaseous tritium. The two sugars are transported into Saccharomyces cerevisiae by both the constitutive glucose and the inducible galactose carrier. Uranyl ions are powerful inhibitors. The pH optimum in uninduced cells lies at 5.5 for both sugars, the apparent activation energies (between 15 and 35 degrees C) are 25.1 kJ/mol and 16.5 kJ/mol, respectively. The steady-state intracellular concentration of both sugars is less than the extracellular one (no uphill transport). Neither of them is a substrate of yeast hexokinase. 4-Deoxy-D-glucose undergoes a dinitrophenol-sensitive conversion to an unknown metabolite which is not phosphorylated and may represent one of its oxidation products.

References

Sep 1, 1969·Journal of Clinical Pathology·M R Lewin
Aug 1, 1968·European Journal of Biochemistry·C F HerediaG DelaFuente

Citations

Oct 4, 1978·Archives of Microbiology·S Stähl
Jun 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·H Bönisch
Dec 1, 1978·Journal of Bioenergetics and Biomembranes·J D Mountz, H T Tien
Jan 1, 1996·International Journal of Legal Medicine·L Pötsch
Aug 15, 2001·Folia Microbiologica·U Khansuwan, A Kotyk
Jan 1, 1978·Folia Microbiologica·A Kotyk, D Michaljanicová
Jan 1, 1985·Folia Microbiologica·A KotykH Sychrová
Jan 1, 1985·Folia Microbiologica·S Janda, A Kotyk
Oct 23, 1986·Biochimica Et Biophysica Acta·J SchuddematJ Van Steveninck
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L F Bisson, D G Fraenkel
May 31, 1977·Biochimica Et Biophysica Acta·A E Shamoo, D A Goldstein
Dec 7, 1981·Biochimica Et Biophysica Acta·R J Turner
Nov 1, 1977·Biochimica Et Biophysica Acta·A Kotyk, R Struzinský
Feb 7, 1981·Journal of Theoretical Biology·A DasguptaJ Das
Jan 1, 1980·Experimental Eye Research·G J PascuzzoE L Pautler
Jan 1, 1981·Critical Reviews in Microbiology·G L Baughman, D F Paris
Sep 27, 1982·Biochimica Et Biophysica Acta·A KotykA Knotková
May 1, 1978·Journal of Gerontological Nursing·L D Spiro

Related Concepts

Deoxy Sugars
Deoxyglucose
Dinitrophenols
Respiratory Chain
Levulosa Ife
Anhydrous Dextrose
Hexokinase 2
Hydrogen-Ion Concentration
Iodoacetamide
Saccharomyces cerevisiae

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