Transport of amino acids by the human placenta: predicted effects thereon of maternal hyperphenylalaninaemia

Journal of Inherited Metabolic Disease
Y Kudo, C A Boyd

Abstract

Brush border and basal plasma membrane vesicles prepared from normal term human placental syncytiotrophoblast have been used to study amino acid transport. Such studies are reviewed and novel results presented which confirm that saturation of placental transport by phenylalanine is unlikely to limit delivery of this amino acid to the fetus even with grossly raised maternal concentrations. Such raised maternal levels of phenylalanine are, however, likely to severely embarrass the delivery to the fetus across the placental brush border membrane of L-tyrosine and, to a lesser extent, of L-tryptophan. Reasons for thinking that this may be relevant to the fetal damage found in maternal PKU are discussed.

References

Jan 29, 1990·Biochimica Et Biophysica Acta·Y Kudo, C A Boyd
Mar 1, 1989·The American Journal of Physiology·S D Hoeltzli, C H Smith
Nov 15, 1986·Biochemical Pharmacology·M E GanapathyV Ganapathy
Aug 15, 1986·The Biochemical Journal·M E GanapathyV Ganapathy
Sep 9, 1985·Biochimica Et Biophysica Acta·D L Yudilevich, J H Sweiry
Jun 1, 1981·The Journal of Physiology·C A Boyd, E K Lund

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Citations

Jan 1, 1996·Acta Paediatrica·Y Kudo, C A Boyd
Jul 1, 1992·Journal of Obstetric, Gynecologic, and Neonatal Nursing : JOGNN·P B Acosta, L Wright
Feb 15, 2001·International Journal of Epidemiology·J E Harding
Mar 1, 1996·Teratology·H L Levy, M Ghavami
Feb 29, 2000·Journal of the Royal Society of Medicine·J Harding
Jan 22, 2005·The Journal of Biological Chemistry·Susanna BodoyJoan Bertran
Mar 1, 1997·Journal of Inherited Metabolic Disease·W Endres

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