Transport of angiotensin peptides across the Caco-2 monolayer

Peptides
Hui-Lee ChuaMei-Lin Go

Abstract

The bidirectional transport of the angiotensin peptides--des-Asp-angiotensin I (DAAI), angiotensins III and IV--were studied using human intestinal Caco-2 monolayers. The peptides had low permeability rates but were relatively stable to enzymatic hydrolysis. DAAI was transported by diffusion while angiotensins III and IV were transported by an energy requiring, carrier-mediated process. The physicochemical properties and solution conformations of the peptides were investigated in an attempt to establish structure-transport correlations. Among the three peptides, DAAI was the most hydrophobic, had the highest hydrogen bonding potential and was the only peptide to have a random solution conformation, as determined from circular dichroism, two-dimensional (1)H NMR and molecular modelling. On the other hand, the more hydrophilic angiotensin IV had less hydrogen bonding potential and a solution conformation characterized by a beta turn. These factors may influence the transport characteristics of DAAI and angiotensin IV.

References

May 12, 1994·European Journal of Pharmacology·M K Sim, R Radhakrishnan
Jan 1, 1996·Journal of Pharmaceutical Sciences·K PalmP Artursson
May 13, 1998·International Journal of Cardiology·M K Sim, L Min
Jul 2, 2003·The Journal of Pharmacy and Pharmacology·Akihiko UrayamaRyohei Kimura

❮ Previous
Next ❯

Citations

Jun 12, 2013·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hua YangHai-Gang Zhang
Aug 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Peter M AbadirJeremy D Walston
Apr 15, 2010·Journal of Experimental Botany·Marzia GiribaldiAndrea Schubert
Apr 23, 2010·Journal of Experimental Botany·Adam Moolna, Caroline G Bowsher
Feb 23, 2012·Journal of Experimental Botany·Candida VanniniMarcella Bracale
Oct 3, 2012·Journal of Experimental Botany·Christian BukhSøren K Rasmussen
Mar 24, 2012·Plant & Cell Physiology·Chia-Hui LinTsai-Yun Lin
Oct 11, 2011·Nucleic Acids Research·Valentina LevaAlessandra Montecucco
Jul 6, 2010·Rheumatology·Daniela BraconiAnnalisa Santucci
Jun 30, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maurizio BruschiEnrico Verrina
Aug 30, 2011·Chemical Senses·Micheline DsamouMartine Morzel
Sep 4, 2015·Journal of Agricultural and Food Chemistry·Long DingJingbo Liu
Feb 19, 2013·Neuropharmacology·Jason J ParisJay P McLaughlin
Jul 18, 2017·Journal of the Science of Food and Agriculture·Yuxing GuoDaodong Pan
Apr 30, 2008·Journal of Agricultural and Food Chemistry·Lin LeiShimin Li
Apr 11, 2019·Journal of Agricultural and Food Chemistry·Liying WangJingbo Liu
Aug 14, 2020·Journal of Agricultural and Food Chemistry·Zhe XuMing Du
Aug 8, 2017·Journal of Agricultural and Food Chemistry·Qingbiao XuJianping Wu
Aug 16, 2017·Journal of Agricultural and Food Chemistry·Long DingJingbo Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.