Transport of CRH from mouse brain directly affects peripheral production of beta-endorphin by the spleen

The American Journal of Physiology
J M MartinsA J Kastin

Abstract

The blood-brain barrier (BBB) regulates the passage of substances between the brain and the periphery. It has not been shown that the secretion from the brain of a small amount of a substance can directly affect the periphery by transport across the BBB. We found that central injection of radioactively labeled corticotropin-releasing hormone (CRH) resulted in the accumulation of intact CRH in the spleen. CRH also increased splenic beta-endorphin, an effect not blocked by pretreatment with dexamethasone. Inhibition of the secretion of CRH from the brain by colchicine resulted in decreased accumulation of CRH in the spleen and also decreased splenic beta-endorphin. Similar findings occurred in the pituitary gland. The results show that the passage of labeled CRH from the brain can directly affect a peripheral organ, thus emphasizing the regulatory function of the BBB.

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Citations

Feb 14, 2008·The Journal of Pharmacology and Experimental Therapeutics·Naoko NonakaWilliam A Banks
Aug 8, 2015·The Journal of Endocrinology·Belkis Gizem UzturkLarry A Feig
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·J SantosM H Perdue
Apr 11, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Barun K ChoudhurySushil K Sarna
Jan 6, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Lisa M StörkelInga Niedtfeld

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