Transport of D-glucose and 2-fluorodeoxyglucose across the blood-brain barrier in humans

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
S G HasselbalchO B Paulson

Abstract

The deoxyglucose method for calculation of regional cerebral glucose metabolism by PET using 18F-2-fluoro-2-deoxy-d-glucose (FDG) requires knowledge of the lumped constant, which corrects for differences in the blood-brain barrier (BBB) transport and phosphorylation of FDG and glucose. The BBB transport rates of FDG and glucose have not previously been determined in humans. In the present study these transport rates were measured with the intravenous double-indicator method in 24 healthy subjects during normoglycemia (5.2 +/- 0.7 mM). Nine subjects were restudied during moderate hypoglycemia (3.4 +/- 0.4 mM) and five subjects were studied once during hyperglycemia (15.0 +/- 0.7 mM). The global ratio between the unidirectional clearances of FDG and glucose (K1*/K1) was similar in normoglycemia (1.48 +/- 0.22), moderate hypoglycemia (1.41 +/- 0.23), and hyperglycemia (1.44 +/- 0.20). This ratio is comparable to what has been obtained in rats. We argue that the global ratio is constant throughout the brain and may be applied for the regional determination of LC. We also determined the transport parameters of the two hexoses from brain back to blood and, assuming symmetrical transport across the BBB, we found evidence of a larger i...Continue Reading

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Citations

Dec 22, 2015·Seminars in Nuclear Medicine·Valentina Di GialleonardoKayvan R Keshari
Nov 5, 2005·Brain Research. Brain Research Reviews·Amina A Qutub, C Anthony Hunt
May 27, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Fawzi BoumezbeurVincent Lebon
Apr 25, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J PfeufferR Gruetter
Oct 13, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·L E FeinendegenK H Thompson
Aug 7, 2001·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S G HasselbalchO B Paulson
Feb 20, 1998·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·S G HasselbalchO B Paulson
May 10, 2001·The Journal of Clinical Endocrinology and Metabolism·S G HasselbalchO B Paulson
Feb 28, 2021·Journal of the American College of Cardiology·Salva R YuristaB Daan Westenbrink
Oct 26, 2013·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Malte F AlfStefanie D Krämer
Jun 29, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Dorothea BuckBernhard Hemmer

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